نتایج جستجو برای: sox17

تعداد نتایج: 360  

Journal: :The Journal of Cell Biology 1996
Y Kanai M Kanai-Azuma T Noce T C Saido T Shiroishi Y Hayashi K Yazaki

The different mRNA isoforms of the mouse Sox17 gene were isolated from adult mouse testis cDNAs. One form (referred to as form Sox17) encodes an Sry-related protein of 419 amino acids containing a single high mobility group box near the NH2-terminus, while the other form (referred to as form t-Sox17) shows a unique mRNA isoform of the Sox17 gene with a partial deletion of the HMG box region. An...

2014
Diva Jonatan Jason R. Spence Anna M. Method Matthew Kofron Katie Sinagoga Leena Haataja Peter Arvan Gail H. Deutsch James M. Wells

SOX17 is a key transcriptional regulator that can act by regulating other transcription factors including HNF1β and FOXA2, which are known to regulate postnatal β cell function. Given this, we investigated the role of SOX17 in the developing and postnatal pancreas and found a novel role for SOX17 in regulating insulin secretion. Deletion of the Sox17 gene in the pancreas (Sox17-paLOF) had no ob...

Background: Acute Myeloid Leukemia (AML) is a group of heterogeneous malignancies caused by defects in differentiation of hematopoietic cells. SRY-box containing gene 17(SOX17) is a transcription factor which plays an important role in several biological processes, including cardiogenesis, angiogenesis, and lymphopoiesis. Aberrant expression of SOX17 has been detected in solid tumors. This stud...

Journal: :The Journal of clinical investigation 2013
Hanseul Yang Sungsu Lee Seungjoo Lee Kangsan Kim Yeseul Yang Jeong Hoon Kim Ralf H Adams James M Wells Sean J Morrison Gou Young Koh Injune Kim

Little is known about the transcriptional regulation of tumor angiogenesis, and tumor ECs (tECs) remain poorly characterized. Here, we studied the expression pattern of the transcription factor Sox17 in the vasculature of murine and human tumors and investigated the function of Sox17 during tumor angiogenesis using Sox17 genetic mouse models. Sox17 was specifically expressed in tECs in a hetero...

2016
Wenli Li Dan Wu Ziyu Niu Dalei Jiang Huan Ma Heming He Xiuli Zuo Xiangjun Xie Yuanlong He

5-Azacytidine is a well-known anticancer drug that is clinically used in the treatment of breast cancer, melanoma and colon cancer. It has been reported that 5-azacytidine suppresses the biological behavior of esophageal cancer cells. However, corresponding mechanisms remain unclear. In this study, using Transwell invasion and cell proliferation assays, we demonstrated that 5-azacytidine signif...

Journal: :Circulation research 2014
Seung-Hun Lee Sungsu Lee Hanseul Yang Sukhyun Song Kangsan Kim Thomas L Saunders Jeong K Yoon Gou Young Koh Injune Kim

RATIONALE The Notch pathway stabilizes sprouting angiogenesis by favoring stalk cells over tip cells at the vascular front. Because tip and stalk cells have different properties in morphology and function, their transcriptional regulation remains to be distinguished. Transcription factor Sox17 is specifically expressed in endothelial cells, but its expression and role at the vascular front rema...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Jiho Sohn JoAnne Natale Li-Jin Chew Shibeshih Belachew Ying Cheng Adan Aguirre Judith Lytle Brahim Nait-Oumesmar Christophe Kerninon Masami Kanai-Azuma Yoshiakira Kanai Vittorio Gallo

Microarray analysis of oligodendrocyte lineage cells purified by fluorescence-activated cell sorting (FACS) from 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP)-enhanced green fluorescent protein (EGFP) transgenic mice revealed Sox17 (SRY-box containing gene 17) gene expression to be coordinately regulated with that of four myelin genes during postnatal development. In CNP-EGFP-positive (CNP...

The way to overcome current limitations in the generation of glucose-responsive insulin-producing cells is selective enrichment of the number of definitive endoderm (DE) progenitor cells. Sox17 is the marker of mesendoderm and definitive endoderm. The aim of the present research was to study the potential of Sox17 knock-in CGR8 mouse embryonic stem (ES) cells to differentiate into insulin produ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Li-Jin Chew Weiping Shen Xiaotian Ming Vladimir V Senatorov Hui-Ling Chen Ying Cheng Elim Hong Susan Knoblach Vittorio Gallo

The SRY-box (Sox) transcription factors regulate oligodendrocyte differentiation, but their signaling targets are largely unknown. We have identified a major signal transduction pathway regulated by Sox containing gene 17 (Sox17) in the oligodendrocyte lineage. Microarray analysis in oligodendrocyte progenitor cells (OPCs) after Sox17 attenuation revealed upregulated genes associated with cell ...

Journal: :Developmental cell 2009
Jason R Spence Alex W Lange Suh-Chin J Lin Klaus H Kaestner Andrew M Lowy Injune Kim Jeffrey A Whitsett James M Wells

The ventral pancreas, biliary system, and liver arise from the posterior ventral foregut, but the cell-intrinsic pathway by which these organ lineages are separated is not known. Here we show that the extrahepatobiliary system shares a common origin with the ventral pancreas and not the liver, as previously thought. These pancreatobiliary progenitor cells coexpress the transcription factors PDX...

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