نتایج جستجو برای: sonophoresis

تعداد نتایج: 83  

Journal: :Journal of Investigative Dermatology 2023

Background: 5-aminolevulinic acid (5-ALA) has a poor penetrance of the skin with topical application, which reduces efficacy Photodynamic therapy (PDT). Sonophoresis involves use sound waves or ultrasonic energy to enhance transdermal delivery drugs. The purpose this study was investigate effects sonophoresis on penetration 5-ALA into skin. Methods: We calculatedin vitrotransdermal accumulation...

2016
Donghee Park Gillsoo Song Yongjun Jo Jongho Won Taeyoon Son Ohrum Cha Jinho Kim Byungjo Jung Hyunjin Park Chul-Woo Kim Jongbum Seo

Sonophoresis can increase skin permeability to various drugs in transdermal drug delivery. Cavitation is recognized as the predominant mechanism of sonophoresis. Recently, a new logical approach to enhance the efficiency of transdermal drug delivery was tried. It is to utilize the engineered microbubble and its resonant frequency for increase of cavitation activity. Actively-induced cavitation ...

2010
Donghee Park Jinhee Yoon Jingam Park Byungjo Jung Hyunjin Park Jongbum Seo

Sonophoresis temporarily increases skin permeability such that medicine can be delivered transdermally. Cavitation is believed to be the predominant mechanism in sonophoresis. In this study, an ultrasound contrast agent (UCA) strategy was adopted instead of low frequency ultrasound to assure that cavitation occurred, and the efficacy of sonophoresis with UCA was quantitatively analyzed by optic...

1998
J. M. Farrell

Transdermal drug delivery (TDD), a painless, non-invasive method of drug delivery, is limited to only a handful of drugs due to the low permeability of skin, The application of low frequency ultrasound significantly enhances transdemal transpor[ of a variety of drugs (sonophoresis), most likely through cavitation-related phenomena. It is unclear whether the primary effect of ultrasound is on th...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2011
Baris E Polat Douglas Hart Robert Langer Daniel Blankschtein

The use of ultrasound for the delivery of drugs to, or through, the skin is commonly known as sonophoresis or phonophoresis. The use of therapeutic and high frequencies of ultrasound (≥0.7MHz) for sonophoresis (HFS) dates back to as early as the 1950s, while low-frequency sonophoresis (LFS, 20-100kHz) has only been investigated significantly during the past two decades. Although HFS and LFS are...

2015
Bin Huang Wei-Jiang Dong Gao-Yi Yang Wei Wang Cong-Hua Ji Fei-Ni Zhou

The purpose of the present study was to develop a novel transdermal drug-delivery system comprising a polyamidoamine dendrimer coupled with sonophoresis to enhance the permeation of diclofenac (DF) through the skin. The novel transdermal drug-delivery system was developed by using a statistical Plackett-Burman design. Hairless male Wistar rat skin was used for the DF-permeation study. Coupling ...

Journal: :Drug delivery 2016
Atul Nayak Hiten Babla Tao Han Diganta Bhusan Das

A study that combines microneedles (MNs) and sonophoresis pre-treatment was explored to determine their combined effects on percutaneous delivery of lidocaine from a polymeric hydrogel formulation. Varying ratios of carboxymethylcellulose and gelatine (NaCMC/gel ranges 1:1.60-1:2.66) loaded with lidocaine were prepared and characterized for zeta potential and particle size. Additionally, variat...

Journal: :Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2015
Kun Loong Lee Yufeng Zhou

Transdermal drug delivery makes a critical contribution to medical practice and some advantages over conventional oral administration and hypodermic injection. Enhancement of percutaneous absorption or penetration of therapeutic agents (ie, drugs and macromolecules) by ultrasound, termed sonophoresis, has been applied and studied for decades. In this study, the penetration percentage through po...

Journal: :Bosnian Journal of Basic Medical Sciences 2008

Journal: :Lasers in surgery and medicine 2010
Jinhee Yoon Donghee Park Taeyoon Son Jongbum Seo J Stuart Nelson Byungjo Jung

BACKGROUND AND OBJECTIVES Various physical methods, such as microneedling, laser ablation, sonophoresis, and sandpaper, have been widely studied to enhance the transdermal delivery of tissue optical clearing (TOC) agents. A previous study demonstrated that the microneedling method could effectively enhance the permeability of a TOC agent through the skin barrier. STUDY DESIGN/MATERIALS AND ME...

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