نتایج جستجو برای: somatic hypermutation
تعداد نتایج: 43405 فیلتر نتایج به سال:
1 1.1 Cis-acting elements in somatic hypermutation 3 1.2 Transacting elements in somatic hypermutation 4 1.2.1 Activation-induced cytidine deaminase (AID) 4 1.2.2 Mismatch repair in somatic hypermutation 9 1.3 Mutation rates measurements 13 1.4. Specific Aims 15 1.4.1. Specific aim 1: Develop a retroviral based point mutation indicator system 15 1.4.2. Specific aim 2: Characterize the IgH major...
A yeast cell culture approach mimics the benefits of somatic hypermutation to accelerate discovery desirable antibodies.
BACKGROUND Immunoglobulin gene somatic hypermutation is a biologically relevant and clinically useful prognostic factor in different types of low-grade B-cell lymphomas, including chronic lymphocytic leukemia, mantle cell lymphoma and splenic marginal zone lymphoma. DESIGN AND METHODS With the aim of identifying surrogate markers of somatic hypermutation, a combined investigation of IgV(H) mu...
During T cell-dependent immune responses in mouse and human, Ig genes diversify by somatic hypermutation within germinal centers. Rabbits, in addition to using somatic hypermutation to diversify their IgH genes, use a somatic gene conversion-like mechanism, which involves homologous recombination between upstream VH gene segments and the rearranged VDJ genes. Somatic gene conversion and somatic...
lmmunoglobulin variable (V) region sequences are tailored to recognize antigen by the process of somatic hypermutation. Somatic hypermutation of V regions can occur either before or after challenge with antigen. When somatic hypermutation occurs before challenge with antigen, the result is to increase the diversity of the preimmune repertoire. When somatic hypermutation occurs in response to an...
In chronic lymphocytic leukemia (CLL), analysis of immunoglobulin heavy chain variable regions for somatic hypermutation identifies 2 prognostic subsets, mutated and unmutated. Investigators have postulated that unmutated and mutated CLL arises from malignant transformation of pre- and post-germinal center (GC) B cells, respectively. Alternatively, unmutated cases may arise from B cells stimula...
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