نتایج جستجو برای: soluble leptin receptor

تعداد نتایج: 677692  

Journal: :journal of research in medical sciences 0
ghorban mohammadzadeh mohammad-ali ghaffari ahmmad bafandeh seyed-mohammad hosseini

background: leptin plays a key role in the regulation of energy expenditure and is known to circulate in both free and bound forms. soluble leptin receptor (sob-r) is a unique circulating form of leptin receptor that can bind to leptin. leptin and leptin receptor have been implicated in processes leading to breast cancer initiation and progression. our study was aimed to investigate the relatio...

Ahmmad Bafandeh Ghorban Mohammadzadeh, Mohammad-Ali Ghaffari, Sayed-Mohammad Hosseini

Objective(s):Leptin receptor (LEPR) is a member of the class I cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. We have investigated the effect of Q223R polymorphism on the breast cancer susceptibly in a sample of Iranian subjects. Materials and Methods:We utilized a polymerase chain reaction (PCR) restriction fragment length polymorphi...

2011
M. Rasjad Indra

One of the five possible mechanisms of leptin resistance in human obesity is the defect in the leptin receptor (Ob-R). Evidence has accumulated that leptin-binding activity in human serum is related to a soluble form of the leptin receptor, and restriction of energy intake resulted a decrease in circulating leptin levels. Aim of this study is to examine the difference of serum soluble leptin re...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2006
Philippe G Cammisotto Diane Gingras Christian Renaud Emile Levy Moïse Bendayan

Leptin is a hormone secreted by the gastric mucosa into the lumen of the stomach. It is present in its intact form in the intestine where it regulates nutrient absorption and intestinal mucosa integrity. We have identified the binding protein that protects leptin from the harsh conditions of the gastric juice. Immunoprecipitations and Western blot analyses demonstrated that leptin is present in...

Journal: :Folia parasitologica 2002
Magdalena Pulido-Mendez Juan De Sanctis Alexis Rodríguez-Acosta

Leptin, which is involved in a range of physiological processes, could be an important factor in the pathogenesis of malaria. We found that levels of leptin in serum and urine in Plasmodium berghei-infected mice increased progressively after infection, reaching a maximum value on day 6 post-infection. Serum values were approximately five-fold higher in infected mice than in non-infected control...

2007
Shmuel E. Cohen Efi Kokkotou Sudha B. Biddinger Tatsuya Kondo Rolf Gebhardt Juergen Kratzsch Christos S. Mantzoros C. Ronald Kahn

Liver-specific insulin receptor knockout (LIRKO) mice display hyperinsulinemia, abnormal glucose metabolism and progressive liver dysfunction. In addition, circulation leptin levels appear to be increased more than 50-fold. However, food intake, body weight and adipose mass are not significantly altered in LIRKO mice compared to wild-type littermates. Using a ligand immunofunctional assay, we f...

Journal: :gene, cell and tissue 0
saeed khosropour department of medical biochemistry, hamedan university of medical sciences, hamedan, ir iran maryam shojaee department of biology, payam noor university of mashhad, mashhad, ir iran; department of biology, payam noor university of mashhad, mashhad, ir iran peyman lotfi department of biology, science and research branch, islamic azad university, tehran, ir iran

Journal: :Endocrine journal 2003
Mercy A Nuamah Norimasa Sagawa Shigeo Yura Hiroko Mise Hiroaki Itoh Yoshihiro Ogawa Kazuwa Nakao Shingo Fujii

To clarify the mechanism of leptin resistance during pregnancy, we measured plasma leptin concentrations, free to total leptin ratio (percent free leptin) and soluble leptin receptor concentrations in pregnant women, and compared the results with those in non-pregnant women. We collected plasma samples from 23 non-pregnant and 31 pregnant women in the third trimester. Plasma samples from 5 preg...

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