Introduction: Psoriasis is an inflammatory skin disease in which abnormal individual immune reactivity plays an important role. Eselectin and P-selectin are adhesion molecules expressed on vascular endothelial cells in several inflammatory skin diseases, including psoriasis. The aim of the present study was to describe selected immunological changes, concerning adhesion molecules status (sEsele...

Background: Pivotal roles of Nerve growth factor (NGF) in the development and survival of both neuronal and non-neuronal cells indicate its potential for the treatment of neurodegenerative diseases. However, investigation of NGF deficits in different diseases requires the availability of properly folded human b-NGF. In previous studies bacterial expression of hNGF demonstrated the feasibility o...

Background and Aims: Q59L mutant of L-asparaginase enzyme from Escherichia coli (E. coli) has been introduced with lower side effects. This version of the enzyme might have potential applications in the treatment of leukemia patients. We utilized SHuffle T7 strain of E. coli, to produce the mutant enzyme in the presence of chaperone molecules. Materials and Methods: Q59LAsp gene was cloned in...

BACKGROUND Increased amounts of soluble E-cadherin (E-cad) have been found in the serum in various cancers, but the role of serum soluble E-cad in the prognosis of breast cancer patients has not been explored in Asian populations. MATERIAL/METHOD Blood samples from 111 consecutive patients diagnosed with breast cancer and 55 healthy controls were investigated.Serum soluble E-cad expression le...

background: in the visceral leishmaniasis (vl), parasites reside in reticuluendothelial system, mainly in macrophages. endothelial selectin (e-selectin) might play an important role in leukocyte-endothelium interactions and inflammatory cell recruitment. the aim of this study was determining e-selectin level and its polymorphism in three groups, patients, seroposi­tive and healthy individuals. ...

iran is the center of origin as well as variation for pomegranate (punica granatum l.). also, iran is one of the most important countries in the world in terms of pomegranate culture and production. monitoring morphological and physiological changes which occur during fruit growth and development is an important determining in orchard management decisions. the aim of the present research was to...

background: escherichia coli (e. coli) is the most extensively used host for the production of recombinant proteins. however, most of the eukaryotic proteins are typically obtained as insoluble, misfolded inclusion bodies that need solubilization and refolding. reteplase as a highly disulfide-bonded recombinant protein is an example of difficult to express protein in e. coli. methods: in this s...

theeffect of salt stress on the pysiological and biochemical responses of the seedlings of eight eucalyptus species viz. e. kingsmillii, e. tetragona, e. salubris, e. occidentali, e. microtheca, e. camaldulensis, e. globules and e. sargentii was analyzed. four month-old seedlings grown in greenhouse were watered by five levels of salt solution (0, 50, 100, 150 and 200 mm of nacl) in five replic...