Lamotrigine is a substituted asymmetric triazine. It is a white to pale cream-coloured powder. It is slightly soluble in ethanol and chloroform, and very slightly soluble in water. The pKa of lamotrigine at 25°C is 5.7. Each Lamictal Dispersible/Chewable tablet also contains calcium carbonate, hydroxypropyl cellulose, aluminium magnesium silicate, sodium starch glycollate, povidone, saccharin s...

DESCRIPTION Zopiclone is a fine white or slightly cream crystalline powder with a melting point of 176-178°C. It is practically insoluble in acetone, soluble in dimethyl formamide and 0.1N hydrochloric acid and freely soluble in chloroform and dichloromethane. Imovane tablets contain 7.5 mg of the active ingredient zopiclone. The tablets also contain lactose, calcium hydrogen phosphate, wheat s...

Cimetidine is an odourless white to off-white powder, which is sparingly soluble in water. Each Magicul tablet contains 200 mg, 400 mg or 800 mg of cimetidine. The tablets also contain maize starch, povidone, microcrystalline cellulose, sodium starch glycollate (Type A), magnesium stearate, Opadry Green OY8830 (ARTG no. 1538) for 200 mg and 800 mg tablets, and Opadry White Y-1-7000 E171 (ARTG n...

In the present research work mouth dissolving tablets of domperidone were developed with superdisintegrants like crospovidone, croscarmellose sodium and sodium starch glycollate in various concentrations like 3%, 4% and 6% w/w by direct compression method. All formulations were evaluated for physical characteristics of compressed tablets such as weight variation, hardness, friability, content u...

aim: to enhance the aqueous solubility of olanzapine by using the solid dispersion technique. solid dispersions of olanzapine were prepared by the dispersion method using using pgs and ssg as carriers. drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

Efavirenz (EFV) tablets of different doses were prepared by a wet granulation process using different superdisintegrants such as crosscarmellose sodium (CCS), sodium starch glycollate (SSG) and crosspovidone (CP) to evaluate the role of different disintegrants on the in vitro release of EFV. Further, the mode of addition of disintegrants on EFV dissolution from tablets containing 600 mg of the ...

Stavudine oral disintegration tablets were formulated to minimize the bitter taste and to reduce the first-pass hepatic metabolism. The various precompression parameters like the angle of repose, bulk density, compressibility index and Hausner's ratio were determined for the powder blend. In this study, 14 formulations of stavudine oral disintegration tablet were prepared by direct compression ...

In the present investigation, the compatibility of Atorvastatin calcium was evaluated with various superdisintegrants and other solid excipients by means of FT-IR and DSC. Several batches of tablets with varying proportion of superdisintegrants were prepared by direct compression techniques. Tablets were also evaluated for different physical properties and in-vitro drug release characteristics ...

Background: The main objective of present research work is to formulate the Carbamazepine as Fast Disintegrating tablets give fast relief and an increase in patient compliance. Carbamazepine, antiepileptic, belongs BCS Class-II used control some types seizures treatment epilepsy Neuropathic Pain by blocking use-dependent sodium channels.
 Methods: powdered materials were compressed direct ...

AIM To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug-carrier ratios such as 1 : 1, 1 : 2, 1 : 4, 1 : 6, 1: 8 and 1 : 10 were tried for optimization. Characterization was done by phase solubility, in-vitro release, saturation solubility, permeat...