the transesterification process of trimethylphosphate with ethanol and isopropanol is examined. it is found that the reaction does not proceed in the absence of base even at temperature up to 100°c, whereas in the presence of sodium alkoxide as a catalyst it takes place at room temperature leading to a mixture of mono-,bi-, tri-substitute esters as well as the minor by-products resulting from t...

The first sodium-magnesium and sodium-zinc ketimido complexes display contrasting inverse crown ring and pseudo-cubane structures respectively, while a sodium-zinc heterotrianionic alkide-alkoxide-amide adopts a third type of structure with a stepped ladder motif.

The transesterification process of trimethylphosphate with ethanol and isopropanol is examined. It is found that the reaction does not proceed in the absence of base even at temperature up to 100°C, whereas in the presence of sodium alkoxide as a catalyst it takes place at room temperature leading to a mixture of mono-,bi-, tri-substitute esters as well as the minor by-products resulting from t...

A new route to α-alkyl-α-fluoromethylenebisphosphonates, 2 has been developed starting from commercially available tetraethyl fluoromethylenebisphosphonate (1), and alkyl halides using either caesium carbonate in DMF or sodium dimsyl. De-esterification of 2 provided biologically important α-alkyl-α-fluoromethylenebisphosphonic acid, 3, while alkoxide-induced carbon-phosphorus bond cleavage of 2...

An all-aqueous sol-gel method for encapsulation of bacterial cells in porous silicate matrices towards the development of a biosensor is described. The sol-gel encapsulation of cells is achieved at room temperature and neutral pH. Furthermore, use of sodium silicate as precursor avoids generation of alcohol that can be detrimental to cells in contrast to the traditional alkoxide sol-gel encapsu...

A three-step procedure has been developed for preparing ortho-alkoxybenzaldehydes from ortho-fluorobenzaldehydes that tolerates the use of sterically hindered sodium alkoxide nucleophiles. The protocol is modular and operationally convenient. The ortho-alkoxybenzaldehyde products can be converted in one additional step to ortho-alkoxystyrenes by a Wittig reaction. These styrenes are precursors ...

Ring cleavage occurred when 1,2,4-triazino-1,2,4-triazines (3), (4) and (5) were treated with concentrated hydrochloric acid to yield N-substituted triazines (7) and (8). These confirm the given configuration assigned to the isomeric triazinotriazines. 6-Methyl-2-phenyl-7H-oxazolo [3,2-b][1,2,4]-triazin-7-one (9) underwent ring cleavage on treatment with sodium alkoxide to afford 3-alkoxy-1...

Some new 2-alkoxy-3-cyano-4,6-diarylpyridines 3,4 were synthesized by condensation of different alpha,beta-unsaturated ketones 1 with malononitrile 2, followed by cyclization in sodium alkoxide/alcohol system. Lewis acid-catalyzed reaction of 4 with hydrazine afforded the corresponding 1H-pyrazolo[3,4-b]pyridines 5. The potency of the results as antimicrobial agents has been evaluated. The stru...

ring cleavage occurred when 1,2,4-triazino-1,2,4-triazines (3), (4) and (5) were treated with concentrated hydrochloric acid to yield n-substituted triazines (7) and (8). these confirm the given configuration assigned to the isomeric triazinotriazines. 6-methyl-2-phenyl-7h-oxazolo [3,2-b][1,2,4]-triazin-7-one (9) underwent ring cleavage on treatment with sodium alkoxide to afford 3-alkoxy-1,2,4...