Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of motor neurons leading to paralysis and death. Mutations of the human Cu/Zn superoxide dismutase (SOD1) are found in some cases of familial ALS (fALS). Recent evidences suggest the accumulation of intracellular calcium is one of the primary mechanisms of motor neuronal degeneration. In th...

Superoxide dismutase [Cu-Zn] 1 (SOD1), is an antioxidant enzyme encoded by the gene SOD1, responsible for regulating oxidative stress levels sequestering free radicals. Identified as first with mutations in Amyotrophic lateral sclerosis (ALS), SOD1 is a determinant studying diseases of aging and neurodegeneration. With guidance on well-ch...

Objective(s): Human superoxide dismutase 1 (SOD1) is the cytosolic form of this enzyme it detoxifies superoxide anions and attenuates their toxicities and concomitant detrimental effects on the cells. It is believed that the amount of these enzymes present in the oxidative stress-induced diseases is crucial for preventing disease progression. Transfection of rat bone marrow stromal cells (BMSCs...

objective(s): amyotrophic lateral sclerosis (als), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in european populations. approximately 10% of als cases are familial (fals) and the other patients are considered as sporadic als (sals). among many als causing genes that have been identified, mutations in sod1 and c9orf72 are the most common genetic causes...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of motor neurons leading to paralysis and death. Mutations of the human Cu/Zn superoxide dismutase (SOD1) are found in some cases of familial ALS (fALS). Recent evidences suggest the accumulation of intracellular calcium is one of the primary mechanisms of motor neuronal degeneration. In th...

Superoxide dismutase [Cu-Zn] 1 (SOD1), is an antioxidant enzyme encoded by the gene SOD1, responsible for regulating oxidative stress levels sequestering free radicals. Identified as first with mutations in Amyotrophic lateral sclerosis (ALS), SOD1 is a determinant studying diseases of aging and neurodegeneration. With guidance on well-ch...

Approximately 10% of the cases of amyotrophic lateral sclerosis (ALS) are inherited, with the majority of identified linkages in the gene encoding Cu/Zn superoxide dismutase (SOD1). Recent studies showed that human wild-type SOD1 (SOD1(WT)) overexpression accelerated disease in mice expressing human SOD1 mutants linked to ALS. However, there is a controversy whether the exacerbation mechanism o...

There is increasing evidence that toxicity of mutant superoxide dismutase-1 (SOD1) in amyotrophic lateral sclerosis (ALS) is linked to its propensity to misfold and to aggregate. Immunotargeting of differently folded states of SOD1 has provided therapeutic benefit in mutant SOD1 transgenic mice. The specific region(s) of the SOD1 protein to which these immunization approaches target are, howeve...

Objective: Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder that causes progressive loss of the upper and lower neurons in brain spinal cord. SOD1 was first gene linked to ALS, which more than 150 mutations throughout sequence protein have been found be associated with ALS. Methods: The drugs can interact inhibit misfolding or revert misconformation useful treatment Monomer ...

compelling evidence suggests that the oxidative stress plays a key role in the pathophysiology of cardiovascular disease (cvd). superoxide dismutase (sod) enzymes play a major role in detoxification of reactive oxygen species and protection against oxidative stress. we examined the possible association between a 50-bp insertion/deletion in the sod1 promoter 1684-bp upstream of the sod1 atg with...