نتایج جستجو برای: socs1 gene

تعداد نتایج: 1141759  

Journal: :iranian journal of basic medical sciences 0
lin liu department of hematology, the second affiliated hospital of kunming medical university, kunming 650101, china lin tan department of hematology, the first affiliated hospital of kunming medical university, kunming 650041, china zhenxin he department of hematology, the first affiliated hospital of kunming medical university, kunming 650041, china

objective(s): the aim of this study was to investigate the methylation status and mrna expression levels of p15, death-associated protein kinase (dapk), and suppressor of cytokine signaling-1 (socs1) genes in multiple myeloma (mm). materials and methods: the bone marrow samples of 54 mm patients were collected and the methylation status of the p15, dapk, and socs1 gene promoter regions was dete...

Journal: :The Journal of Experimental Medicine 2004
Takafumi Yoshida Hisanobu Ogata Masaki Kamio Akiko Joo Hiroshi Shiraishi Yoko Tokunaga Michio Sata Hisaki Nagai Akihiko Yoshimura

Hepatocellular carcinomas (HCCs) mainly develop from liver cirrhosis and severe liver fibrosis that are established with long-lasting inflammation of the liver. Silencing of the suppressor of the cytokine signaling-1 (SOCS1) gene, a negative regulator of cytokine signaling, by DNA methylation has been implicated in development or progress of HCC. However, how SOCS1 contributes to HCC is unknown...

Journal: :Molecular medicine reports 2012
Yan-Rong Qian Qiu-Rui Zhang Ting Cheng Huan-Ying Wan Min Zhou

Suppressor of cytokine signaling-1 (SOCS1) is a protein that negatively regulates cytokine and growth factor signaling. However, little is known regarding the precise role it plays in idiopathic pulmonary fibrosis. The aim of the present study was to construct a recombinant lentiviral vector for RNA interference targeting the SOCS1 gene and to detect the expression in human alveolar epithelial ...

Objective(s): The aim of this study was to investigate the methylation status and mRNA expression levels of P15, death-associated protein kinase (DAPK), and suppressor of cytokine signaling-1 (SOCS1) genes in multiple myeloma (MM). Materials and Methods: The bone marrow samples of 54 MM patients were collected and the methylation status of the P15, DAPK, and SOCS1 gene promoter regions was dete...

2014
X Zhang J Wang J Cheng S Ding M Li S Sun L Zhang S Liu X Chen H Zhuang F Lu

Persistent inflammation together with genetic/epigenetic aberrations is strongly associated with chronic Hepatitis B virus (HBV) infection-related hepatocarcinogenesis. Here, we investigated the alterations of the suppressor of cytokine signalling (SOCS) family genes in HBV-related hepatocellular carcinoma (HCC). A total of 116 patients with HCC were enrolled in this study. The methylation stat...

2013
Birgit Schif Jochen K. Lennerz Christian W. Kohler Stefan Bentink Markus Kreuz Ingo Melzner Olga Ritz Lorenz Trümper Markus Loeffler Rainer Spang Peter Möller

Suppressor of cytokine signaling 1 (SOCS1) is frequently mutated in primary mediastinal and diffuse large B-cell lymphomas (DLBCL). Currently, the prognostic relevance of these mutations in DLBCL is unknown. To evaluate the value of the SOCS1 mutation status as a prognostic biomarker in DLBCL patients, we performed full-length SOCS1 sequencing in tumors of 154 comprehensively characterized DLBC...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Hong Zhou Rika Miki Mervi Eeva Francesca M Fike David Seligson Lu Yang Akihiko Yoshimura Michael A Teitell Christina A M Jamieson Nicholas A Cacalano

PURPOSE The expression of suppressors of cytokine signaling 1 (SOCS1) and SOCS3 genes is dysregulated in several solid tumors, causing aberrant activation of cell growth and survival signaling pathways. In this study, we analyzed SOCS1 and SOCS3 gene expression in glioblastoma multiforme (GBM) and studied the role of each protein in GBM cell signaling and radiation resistance. EXPERIMENTAL DE...

2017
Liang Zhou Ningfu Wang Hong Li Guoxin Tong Jianmin Yang Lei Lai Hao Pan Xianhua Ye Jinyu Huang

BACKGROUND Inflammation is involved in the development of In-stent restenosis (ISR) after percutaneous coronary intervention. We aimed to investigate the association between of suppressor of cytokine signaling-1 (SOCS1), a major negative regulator for inflammation, and the occurrence of ISR in Chinese patients. METHODS We enrolled patients with coronary artery disease who underwent PCI with s...

2015
William S. Tobelaim Claudia Beaurivage Audrey Champagne Véronique Pomerleau Aline Simoneau Walid Chababi Mehdi Yeganeh Philippe Thibault Roscoe Klinck Julie C. Carrier Gerardo Ferbeyre Subburaj Ilangumaran Caroline Saucier

The SOCS1 (Suppressor Of Cytokine Signalling 1) protein is considered a tumour suppressor. Notably, the SOCS1 gene is frequently silenced in cancer by hypermethylation of its promoter. Besides blocking inflammation, SOCS1 tumour suppressor activity involves Met receptor inhibition and enhancement of p53 tumour suppressor activity. However, the role of SOCS1 in colorectal cancer (CRC) remains un...

Journal: :Journal of immunology 2002
Subburaj Ilangumaran Dina Finan José La Rose Jason Raine Anna Silverstein Paulo De Sepulveda Robert Rottapel

Suppressor of cytokine signaling 1 (SOCS1) is rapidly induced following stimulation by several cytokines. SOCS1 negatively regulates cytokine receptor signal transduction by inhibiting Janus family tyrosine kinases. Lack of such feedback regulation underlies the premature death of SOCS1(-/-) mice due to unbridled IFN-gamma signaling. We used mouse embryo fibroblasts derived from SOCS1(-/-) mice...

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