background it has been reported that systemic administration of allopurinol improves cell survival. this study was aimed to evaluate effects of allopurinol on skin flaps in dogs. methods twenty dogs underwent one skin flap surgery with a 2-week interval. the first procedure was performed according to the standard protocols. the second phase was started by a 1-week pretreatment with allopurinol....

closure of donor site of the flap has special problems. reduction of this site will decrease the morbidity of operation. in this study, we present our experience in donor site size reduction. methods between 2006 and 2008, 15 patients with skin and soft tissue defects underwent operation. in all patients, coverage of defect was performed with various flaps. substratum horizontal mat-tress sutur...

background necrosis of skin flaps is considered as an important complication in reconstructive surgery. we conducted an experimental study to investigate the efficacy of low-molecular weight heparin, clopidogrel and their combination to improve the flap survival. methods forty male, adult sprague-dawlay rats were divided randomly into 4 groups. standard rectangular, distally based dorsal random...

despite all modern surgical techniques, skin flap that is considered as the main method in most reconstructive surgeries puts the skin tissue at danger of necrosis and apoptosis derived from ischemia. therefore, finding a treatment for decreasing the apoptosis derived from flap ischemia will be useful in clinic. in present study, we evaluated the effect of azelaic acid 20% and finasteride on ex...

background: skin flap grafting is a popular approach for reconstruction of critical skin and underlying soft tissue injuries. in a previous study, we demonstrated the beneficial effects of two 5α-reductase inhibitors, azelaic acid and finasteride, on tissue survival in a rat model of skin flap grafting. in the current study, we investigated the involvement of nitric oxide and inducible nitric o...

Despite all modern surgical techniques, skin flap that is considered as the main method in most reconstructive surgeries puts the skin tissue at danger of necrosis and apoptosis derived from ischemia. Therefore, finding a treatment for decreasing the apoptosis derived from flap ischemia will be useful in clinic. In present study, we evaluated the effect of azelaic acid 20% and finasteride on ex...

BACKGROUND One of the main challenges in skin flap surgery is tissue ischemia and following necrosis. The present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model. METHODS Thirty rats were allocated into 3 groups (n=10) and 2×8 cm dorsal rando...

introduction: providing the material for penile reconstruction after release of chordee associated with hypospadias is challenging. we have used the preputial vascularized island flap for this purpose. we report the results of this prospective study. materials and methods: one hundred and twelve boys ranging from 13 months to 12 years of age were enrolled in this study. the location of meatus r...