Background and aim: The skin has some appendages that give origin to various tumors. These tumors are generally divided to pilosebaceous and sweat glands tumors according to embryologic and histological features. Clinical and histological characteristics of these tumors are also divergent. In addition, classification of them according to histological background has been changed considerably in ...

Clear cell hidradenoma is a rare skin appendage tumor. A 41-year-old female presented with right gluteal mass. Excisional biopsy of the mass was performed. Under the epidermis, an eosinophilic-cytoplasm, uniform-appearance, oval-round-nucleus, benign tumor with cystic and solid components was detected. These results were consistent with clear cell hidradenoma. The patient had not been given pos...

Nevus lipomatosus superficialis is a rare type of connective tissue nevus. Cylindroma is a benign skin appendage tumor with a predilection for the scalp of older females. We describe the case of a 56-year-old woman with a scalp lesion demonstrating histopathologic features consistent with benign cylindroma arising within a nevus lipomatosus superficialis. To our knowledge, this lesion has not b...

Various benign and malignant non-melanocytic tumors, including skin appendage tumors, sometimes accompany non-neoplastic melanocytes, and this phenomenon has been described as “melanocytic colonization” [1-7]. Porocarcinoma is a rare skin appendage carcinoma related to the sweat gland duct, originally described by Pinkus and Mehregan in 1963 [8]. Its incidence is reported to be 0.004% of skin b...

Tumor-to-tumor metastasis is a rare phenomenon, but it has been suggested to be more frequent in patients with hereditary cancer syndrome. We report an autopsy case of tumor-to-tumor metastasis in a 75-year-old male. At 6 months before his death, the patient complained of hoarseness and dysphagia, and clinical whole-body examinations revealed advanced lung adenocarcinoma (T4N2M1b, Stage IV), mu...

Pilomatricoma, a benign skin appendage tumor, also known as calcifying epithelioma, consists of islands epithelial cells histologically that contain anucleated in the center surrounded by basophilic and partial calcification. Sporadic pilomatricomas commonly have somatic mutations gene CTNNB1, but causative genes from germline underlying pathophysiology are unclear. In this study, we identified...

Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and regeneration. These stem cells also participate in the repair of the epidermis after injuries, inducing restoration of tissue integrity and function of damaged tissue. Unlike epidermis-derived stem cells, comprehensive knowledge about skin appendage-derived stem cells remains limited. In this review...

We herein report a glycogen-rich adenocarcinoma occurring in the lower lip of a 44-year-old female. The lesion appeared as painless slowly growing mass in the right side of the lower lip. Histologically, infiltrative tumor nests with duct-like or pseudocyst structure into the mucosa and/or dermis were observed. The basaloid neoplastic cells had granular but occasionally vacuolated cytoplasm wit...