SK channels are upregulated in human patients and animal models of heart failure (HF). However, their activation mechanism and function in ventricular myocytes remain poorly understood. We aim to test the hypotheses that activation of SK channels in ventricular myocytes requires Ca(2+) release from sarcoplasmic reticulum (SR) and that SK currents contribute to reducing triggered activity. SK2 c...

AIMS We examined the thermoregulatory response to heat exposure in patients with chronic heart failure. METHODS AND RESULTS Skin blood flow (SkBF) was measured in HF subjects and matched controls. Cutaneous vascular conductance (CVC) was calculated from laser-Doppler SkBF and blood pressure. To assess the nitric oxide contribution to thermoregulatory responses, subcutaneous microdialysis memb...

It has been attempted in this laboratory for the past years to isolate and passage herpes simplex virus by the chorioallantoic inoculation of embryonated eggs and pursue the changes in pathogenicities for various host animals occurring during the course of the passage. Among the pathogenicities examined were included those for baby mice intracerebrally or intraperitoneally inoculated, since Kil...

OBJECTIVE The objective of the study was to observe the effect of controlled breathing exercises including Sudarshan Kriya (SK) and Prana-Yoga (PY) on the psycho-physiological status. METHODS The study group included 60 healthy volunteers (M:30, F:30) in the age group of 18 to 30 years (21.3 ± 3.2 yrs), randomly divided in to three groups of 20 subjects each--(1) The SK group (2) the PY group...

Genetic factors play a substantial role in susceptibility to common diseases such as type 2 diabetes (T2DM) and obesity-related disorders. The current investigation was undertaken to examine the association of genetic variants that indirectly affect diabetesrelated traits through their effects on birth weight and adiposity in South Asian Indians. Additionally, the thesis was extended to examine...

penfluridol, a neuroleptic drug, considerably reversed halofantrine resistance in t9.96hf halofantrine resistant strain of plasmodium falicparum (originally chloroquine sensitive parasites), but not in k1hf halofantrine resistant strain (originally chloroquine resistant parasites)

A study has been made of the local effects following intramuscular injection of various neurotropic viruses. Early massive necrosis of muscle fibers accompanied by edema and acute inflammatory reaction is produced by Jungeblut's SK virus even in low concentrations. Similar but more slowly developing lesions follow the introduction of mouse encephalomyelitis GD-VII and FA strains. Strain 4727 (T...