introduction: cisplatin is an antineoplastic drug, which is widely used for the treatment of solid tumors. however, its clinical usage is limited because of its side effects such as hepatotoxicity. this study aimed to identify toxic effects of cisplatin on hepatocytes of rats. methods: a total of 45 adult sprague dawley rats weighing 200±30 g were randomly divided into experimental (n=30) and c...

In this experiment effect of two full and half width sinusoidal inner tubes in triplex-tube heat exchanger with phase change material (PCM) was investigated. Length and diameter of the tubes have been chosen such that the area of each tube to be the same. Charging and discharging processes were carried out by inner tube, outer tube and both. Results indicated, PCM melting and solidification tim...

The endocytosis of tracer particles by sinusoidal endothelial cells was studied in the bone marrow and liver of the rabbit and in the bone marrow of the rat after intravenous injection. The tracer particles used included carbon particles and polystyrene particles of different sizes ranging from 0.11 to 5.7 micron in diameter. The sinusoidal endothelial cells of the rabbit liver and rat bone mar...

BACKGROUND It has been postulated that ethanol affects hepatic sinusoidal and perisinusoidal cells. In the current experimental study, we investigated the early effect of a single intravenous dose of ethanol on the diameter of liver sinusoidal endothelial fenestrae in New Zealand White rabbits. The diameter of fenestrae in these rabbits is similar to the diameter found in humans with healthy li...

We examined liver specimens from 15 patients with uveal melanoma (UM) who had died of their disseminated disease. We found 2 distinct growth patterns of UM metastasis: infiltrative (n = 12) and nodular (n = 3). In the infiltrative pattern, individual UM cells with a CD133+ cancer stem cell-like phenotype were present and formed aggregates of stage I <50-μm-diameter micrometastases in the sinuso...

We propose a method for obtaining an improved representation of transients in audio signals. The representation is based on a damped sinusoidal model. To improve the representation, transient locations are modified in such a way that a transient can start only at the beginning of a sinusoidal segment. The introduced modifications facilitate a reduction of the number of damped sinusoids needed t...

We crafted human immunodeficiency virus (HIV)-like particles of diameter about 140 nm, which expressed two major HIV-1 proteins, namely, env and gag gene products, and used this reagent to simulate the rate of decay of HIV from the blood stream of BALB/c male mice. We found that most (~90%) of the particles were eliminated (cleared) from the blood by the liver sinusoidal endothelial cells (LSEC...

The whole body including extended processes of Ito's fat-storing cells was observed by scanning electron microscopy in rat liver injured with lithocholic acid (LCA). Necrotic foci developed in the midlobular zone 48 h after LCA administration. Demonstration of Ito cell bodies around the foci was probably facilitated by easy detachment of hepatocytes from Ito cells. The body and the processes we...

Introduction: Cisplatin is an antineoplastic drug, which is widely used for the treatment of solid&nbsp;tumors. However, its clinical usage is limited because of its side effects such as hepatotoxicity.&nbsp;This study aimed to identify toxic effects of cisplatin on hepatocytes of rats. Methods: A total of 45 adult Sprague Dawley rats weighing 200&plusmn;30 g were randomly&nbsp;divided into ex...