In the petroleum supply chain, oil refined products are often delivered to distribution centers by pipelines since they provide the most reliable and economical mode of transportation over large distances. This paper addresses the optimal scheduling of a complex pipeline network with multiple branching lines. The main challenge is to find the optimal sequence and time of product injections/deli...

Centralizing and using proper transportation facilities cut down costs and traffic. Hub facilities concentrate on flows to cause economic advantage of scale and multimodal transportation helps use the advantage of another transporter. A distinctive feature of this paper is proposing a new mathematical formulation for a three-stage p-hub location routing problem with simultaneous pick-ups and de...

The Vehicle Routing Problem with Simultaneous Deliveries and Pickups (VRPSDP) has attracted great interest in research due to its potential cost savings to transportation and logistics operators. There exist several extensions of VRPSDP, and among these extensions, Simultaneous Deliveries and Pickups with Split Loads Problem (SDPSLP) is particularly proposed for eliminating the vehicle capacity...

introduction: ghrelin increases growth hormone secretion and food intake. growth hormone (gh), steroid hormones and opioids are involved in the regulation of food intake. so, they may have a role in the regulation of ghrelin secretion. we determined the effect of intravenous injections of progesterone, gh and morphine or co-administration of these hormones on ghrelin concentration and body weig...

centralizing and using proper transportation facilities cut down costs and traffic. hub facilities concentrate on flows to cause economic advantage of scale and multimodal transportation helps use the advantage of another transporter. a distinctive feature of this paper is proposing a new mathematical formulation for a three-stage p-hub location routing problem with simultaneous pick-ups and de...

DNA-based immunizations have been used to determine the patterns of type 1 and type 2 cytokines that can be induced in vivo for Ag-specific CD4(+) and CD8(+) T cells. IL-4 was used as a signature cytokine for a type 2 T cell response and IFN-gamma as the signature cytokine for a type 1 response. Gene gun deliveries of secreted Ags were used to bias responses toward type 2 and saline injections ...

We introduce and solve the Vehicle Routing Problem with Simultaneous Pick-ups and Deliveries and TwoDimensional Loading Constraints (2L-SPD). The 2L-SPD model covers cases where customers raise delivery and pick-up requests for transporting non-stackable rectangular items. 2L-SPD belongs to the class of composite routing-packing optimization problems. However, it is the first such problem to co...