Even though the high-temperature formability of Al alloys can be enhanced by the strain-induced melt activation (SIMA) process, the mechanical properties of the formed alloys are necessary for estimation. In this research, a modified two-step SIMA (TS-SIMA) process that omits the cold working step of the traditional SIMA process is adopted for the 6066 Al-Mg-Si alloy to obtain globular grains w...

This paper describes the hardware implementation of Simple Integrated Media Access (SIMA) access node. SIMA introduces Quality of Service (QoS) in IP networks by using the IPv4 Type of Service (TOS) field as priority and real-time indication field. Hardware acceleration is used to speed up the SIMA cal-culations.

The basic objectives of future Internet are to increase the network capacity, to offer a practical real-time service, and to develop a feasible charging scheme. These objectives introduce very strict requirements for the trafilc control system. This paper presents a new simple approach for traffic management: Simple Integrated Media Access (SIMA). According to the SIMA concept each customer sha...

BACKGROUND Streptococcus iniae is a significant pathogen in finfish aquaculture, though knowledge of virulence determinants is lacking. Through pyrosequencing of the S. iniae genome we have identified two gene homologues to classical surface-anchored streptococcal virulence factors: M-like protein (simA) and C5a peptidase (scpI). METHODOLOGY/PRINCIPAL FINDINGS S. iniae possesses a Mga-like lo...

Simvastatin (SIM) is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor widely used in hyperlipidemia therapy. SIM has recently been studied for its anticancer activity at doses higher than those used for the hyperlipidemia therapy. This prompted us to study the pharmacokinetics of high-dose SIM in cancer patients. For this purpose, an LC-MS/MS method was developed to measure SIM and i...

A modified strain-induced melting activation (SIMA) process is shown to improve high-temperature formability. The microstructural characteristics of the spheroidized grains of SIMA-processed alloys affect high-temperature formability. The effects of hot extrusion parameters and chemical composition on the evolution of spheroidized grains were investigated using several 6xxx series aluminum allo...

The Drosophila melanogaster (Dm) similar (sima) gene was isolated using a low-stringency hybridization screen employing a Dm single-minded gene basic helix-loop-helix (bHLH) DNA probe. sima is a member of the bHLH-PAS gene family and the conceptual protein shares a number of structural features, including a bHLH domain, PAS domain, and homopolymeric amino acid stretches. Sima is most closely re...

AIMS Observational data suggest that the use of bilateral internal mammary arteries (BIMA) during coronary artery bypass graft surgery provides superior revascularization to a single internal mammary artery (SIMA), but concerns about safety have prevented the widespread use of BIMA. The Arterial Revascularisation Trial (ART) is a randomized trial of BIMA vs. SIMA, with a primary outcome of surv...

Fungi are adept at occupying specific environmental niches and often exploit numerous secondary metabolites generated by the cytochrome P450 (CYP) monoxygenases. This report describes the characterization of a yeast-specific CYP encoded by simA ("survival in macrophages"). Deletion of simA does not affect yeast growth at 37°C in vitro but is essential for yeast cell production during macrophage...

During the night, on September 2004, Jina called for an ambulance after Sima had trouble breathing and then accompanied her to the hospital. Sima was hospitalized and I came to visit them the next morning at 11:30 am in the ward. After an hour, the nurse entered the room and declared that visiting hours were over. While I prepared to take my things I asked Jina whether she was planning to stay ...