نتایج جستجو برای: signaling molecules
تعداد نتایج: 471054 فیلتر نتایج به سال:
scientific evidence regarding the efficacy and safety of the ldm approach in the treatment of psoriasis vulgaris, and positive preliminary data regarding the oral administration of low dose activated cytokines for vitiligo and atopic dermatitis treatment, support the ldm-based therapeutic approach for many dermatological diseases. ldm suggests the use of low-doses of activated biological molecu...
Primordial Germ Cells (PGCs) are unipotent precursors of the gametes. PGCs can give rise to a type of pluripotent stem cells in vitro that are called embryonic germ (EG) cells. PGCs can also acquire such pluripotency in vivo and generate teratomas. Under specific culture conditions, PGCs can be reprogrammed to embryonic germ cells which are capable of expression of key pluripotency marker...
Basal cell carcinoma (BCC) is the most common cancer in Iran and in the world and its prevalence may become equivalent to the prevalence of all other cancers combined in the future. The Hedgehog (Hh) signaling pathway has an important role in tumorigenesis of BCC. Mutations in PTCH and Smo molecules of this pathway account for 85% to 95% of sporadic BCCs and also most cases of inherited cases. ...
Objective(s): Chronic myeloid leukemia (CML) is a myeloid clonal proliferation disease defining by the presence of the Philadelphia chromosome that shows the movement of BCR-ABL1. In this study, the critical role of the Musashi2-Numb axis in determining cell fate and relationship of the axis to important signaling pathways such as Hedgehog and Notch that are essential ...
single-gene disorders occur when mutation in a gene causing alteration of gene function while in multifactorial disorders, mutations occur in multiple genes, and these are usually coupled with environmental causes. in addition, in a multifactorial disorder such as diabetes, the complication is under the influence of different genes. for example, in diabetic retinopathy many genes are involved i...
Single-gene disorders occur when mutation in a gene causing alteration of gene function while in multifactorial disorders, mutations occur in multiple genes, and these are usually coupled with environmental causes. In addition, in a multifactorial disorder such as diabetes, the complication is under the influence of different genes. For example, in diabetic retinopathy many genes are involved i...
Arabinogalactan proteins (AGP) are a class of cell surface plant peptidoglycans which have been implicated in root elongation and signal transduction pathways. AGPs function not only as markers of cellular identity but also as signaling molecules, which might initiate signal transduction. Aluminum promotes the elongation of tea (Camellia sinensis L.) roots. Although some mechanisms by which Al ...
Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host cells but control the process. Today, transcription factors required for retinal progenitor cells are well known, but the generation of these ...
toll-like receptor 4 (tlr4), considered one of the most important tlr, recognizes lipopolysaccharide of gram-negative bacteria. recognition of ligands by tlrs induces signaling pathways resulting in activation of transcriptional factors such as nf-κb which are involved in the expression of inflammatory cytokines and chemokines. to prevent an inappropriate immune response, a complex ...
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