introduction: atherosclerosis, hypertension, ischemic diseases, alzheimer’s disease, parkinson disease, cancer and inflammation emerge from imbalance between antioxidant and oxidants. cancer is a most important public health problem in both developed and developing countries. natural antioxidants such as polyphenols are being used for prevention and treatment cancer. polyphenols include phenoli...

cyclooxygenase-2 (cox-2) has a pivotal role in the pathogenesis of the lung cancer. it is known that cox-2 negatively regulates the activity of a number of tumor suppressors, including p53. consequently, inhibition of cox-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. in this regard, we investigated the effect of cox-2 signaling blockade on p53 and cox-2 e...

Cyclooxygenase-2 (COX-2) has a pivotal role in the pathogenesis of the lung cancer. It is known that COX-2 negatively regulates the activity of a number of tumor suppressors, including p53. Consequently, inhibition of COX-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. In this regard, we investigated the effect of COX-2 signaling blockade on p53 and COX-2 e...

Cyclooxygenase-2 (COX-2) has a pivotal role in the pathogenesis of the lung cancer. It is known that COX-2 negatively regulates the activity of a number of tumor suppressors, including p53. Consequently, inhibition of COX-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. In this regard, we investigated the effect of COX-2 signaling blockade on p53 and COX-2 e...

objective(s):multidrug resistance (mdr) of cancer cells is a major obstacle to successful chemotherapy. overexpression of breast cancer resistance protein (bcrp) is one of the major causes of mdr. in addition, it has been shown that pi3k/akt signaling pathway involves in drug resistance. therefore, we evaluated the effects of novel approaches including sirna directed against bcrp and targeted t...

Objective(s):Multidrug resistance (MDR) of cancer cells is a major obstacle to successful chemotherapy. Overexpression of breast cancer resistance protein (BCRP) is one of the major causes of MDR. In addition, it has been shown that PI3K/Akt signaling pathway involves in drug resistance. Therefore, we evaluated the effects of novel approaches including siRNA directed against BCRP and targeted t...

chronic myeloid leukemia (cml) is a myeloproliferative disease of the hematopoietic stem cells, characterized by the presence of the philadelphia (ph) chromosome. although imatinib inhibits the bcr-abl kinase activity, clinical experiences confirm that imatinib may not target cml stem cells in vivo. the identification of signaling pathways responsible for the self-renewal properties of leukemic...

Background and objectives: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inhibition results in an increase in apoptosis. It has been demonstrated that NF-κB subunit p65 phosphorylation at the IκB kinase phosphorylation site serine 536 (Ser536) is essential for the NF-κB nuclear translocation and activation. Therefore, NF-κB can be downregulated by suppressing its phosph...

objective(s): yu-ping-feng-san (ypfs) is a classical traditional chinese medicine that is widely used for treatment of the diseases in respiratory systems, including chronic obstructive pulmonary disease (copd) recognized as chronic inflammatory disease. however, the molecular mechanism remains unclear. here we detected the factors involved in transforming growth factor beta 1 (tgf-β1)/smad2 si...