Dear Editor, Sideroblastic anemia is a heterogeneous disorder that is characterized by increased serum iron and ferritin levels, high number of hypochromic red blood cells (RBCs), and ineffective erythropoiesis with ringed sideroblasts in the bone marrow (BM) [1]. There are two forms of sideroblastic anemia: inherited and acquired. Acquired sideroblastic anemia usually develops because of alcoh...

Five of seven patients with idiopathic refractory sideroblastic anemia carried an HLA-A3 alloantigen (relative risk, 7.3; P = 0.02). The significance of this association was strengthened by study of two pedigrees. An abnormality in iron metabolism was found in two siblings who had an HLA-A3,B14 haplotype in common with the first proband. A second proband with idiopathic refractory sideroblastic...

mitochondrial myopathy, lactic acidosis, and sideroblastic anemia (mlasa) syndrome is a rare autosomal recessive disorder of oxidative phosphorylation and iron metabolism. the association between myopathy and sideroblastic anemia was initially reported in 1974. here we report an 8.5 year old boy with normal cognitive function, suffering from chronic progressive weakness in his lower extremities...

Sideroblastic anemia is a rare cause of anemia. Most it accounts for the genetic cause, while drug induced still uncommon. Our patient, 20 year old female, known case right frontal tuberculoma on ATT presented with complaints generalized weakness and loss appetite. On evaluation, she was found to have severe bone marrow studies confirmed be sideroblastic revisiting history, noted that not takin...

In a 10-yr observation period, 75 patients with multiple myeloma have been studied, and 55 of these were treated daily with low dose melphalan by mouth. Of these, four developed sideroblastic anemia, manifested by anemia, thrombocytopenia, aniso-poikilocytosis, and hypochromic stippled cells in the blood, and ringed sideroblasts in the bone marrow. In two patients, this complication occurred af...

Activities of mitochondrial enzymes in blood cells from 69 patients with primary sideroblastic anemia were determined to elucidate the pathogenesis of the disease. In erythroblasts of patients with primary acquired type the activities of both delta-aminolevulinic acid synthetase and mitochondrial serine protease were inevitably decreased. The susceptibility to the protease of apo-delta-aminolev...

Sheehan’s syndrome (SS) or pituitary necrosis of the postpartum is a rare pathology and difficult to diagnose that can be life-threatening [1]. Microcytic anemia frequently associated with iron deficiency, sideroblastic anemia, inflammatory thalassemia [2] but rarely SS.

When first defined 50 years ago, sideroblastic anemia (SA) was already recognized to occur in heterogeneous settings, including as familial or acquired disease. The spectrum of SA has since become considerably expanded with respect to distinct clinical phenotypes as well as discrete causes. The singular feature that typifies all forms of SA and is required for initial diagnosis is the presence ...