نتایج جستجو برای: shrinked
تعداد نتایج: 34 فیلتر نتایج به سال:
HTS hit 7 was modified through hybrid design strategy to introduce a chiral side chain followed by introduction of Michael acceptor group to obtain potent EGFR kinase inhibitors 11 and 19. Both 11 and 19 showed over 3 orders of magnitude enhanced HCC827 antiproliferative activity compared to HTS hit 7 and also inhibited gefitinib-resistant double mutant (DM, T790M/L858R) EGFR kinase at nanomola...
Adult Mice (BWt. 30 gms and 40gms) were treated at a 5mg\kgBWt. and 10 mg/kg BWt. of Ethidium Bromide for 10 days in drinking water. Control animals were given equal dose of deionised water. Quantitative and qualitative changes were studied in Spleen. The following features were evaluated: the overall cellularity of the spleen was noticed. The changes were characterised by, injury to spleen tis...
The thorny headed acanthocephan, Pallisentis nagapurensis infects the intestine of fresh water murrel, Channa striatus. This parasite broughts severe histopathological changes in the intestine includes mucosa and submucosa are completely disrupted, thickened lamina propria, damage of epithelial cells, mucosa folds clumped. The intestinal villi of the mucosa shrinked, infected intestine often en...
CONTEXT Botulism is an important public health problem in Argentina, but obtaining antitoxin rapidly has been difficult because global supplies are limited. In January 1998, a botulism outbreak occurred in Buenos Aires. OBJECTIVES To determine the source of the outbreak, improve botulism surveillance, and establish an antitoxin supply and release system in Argentina. DESIGN, SETTING, AND PA...
A manifest covariant equilibrium statistical mechanics is constructed starting with a 8N dimensional extended phase space which is reduced to the 6N physical degrees of freedom using the Poincaré-invariant constrained Hamiltonian dynamics describing the micro-dynamics of the system. The reduction of the extended phase space is initiated forcing the particles on energy shell and fixing their ind...
This paper introduces a new signal denoising based on the Empirical mode decomposition (EMD) framework. The method is a fully data driven approach. Noisy signal is decomposed adaptively into oscillatory components called Intrinsic mode functions (IMFs) by means of a process called sifting. The EMD denoising involves filtering or thresholding each IMF and reconstructs the estimated signal using ...
An apparent sudden change in the outburst recurrence time displayed by the Rapid Burster occurred around the end of 1999. The time between consecutive outbursts shrinked from 200 to 100 days somewhere between November 1999 and March 2000. In parallel, the average peak intensity also decreased of a factor 2 in all outbursts occurred after November 1999 with respect to those occurred before this ...
Designing a new application of knowledge discovery is a very tedious task. The success is determined to a great extent by an adequate example representation. The transformation of given data to the example representation is a matter of feature generation and selection. The search for an appropriate approach is difficult. In particular, if time data are involved, there exist a large variety of h...
We investigate the modulation of turbulence caused by presence finite-size dispersed particles. Bluff (isotropic) spheres vs slender (anisotropic) fibers are considered to understand influence object shape on altering carrier flow. While at a fixed mass fraction - but different Stokes number both objects provide similar bulk effect characterized large-scale energy depletion, scale-by-scale anal...
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