نتایج جستجو برای: shigella flexneri
تعداد نتایج: 6203 فیلتر نتایج به سال:
background and objectives: shigellosis is an acute gastroenteritis that is one of the most common causes of morbidity and mortality in children with diarrhea in developing countries. the purpose of this study was to describe the distribution of shigella serogroups and serotypes and their antibacterial drug resistance profiles. materials and methods: fecal samples of all children suffering from ...
BACKGROUND Shigella, a major diarrheal disease pathogen worldwide, is the target of vaccine development. The Global Enteric Multicenter Study (GEMS) investigated burden and etiology of moderate-to-severe diarrheal disease in children aged <60 months and matched controls without diarrhea during 3 years at 4 sites in Africa and 3 in Asia. Shigella was 1 of the 4 most common pathogens across sites...
background: essential oils and their major constituents are useful sources of antimicrobial compounds. there are a few reports on the decontamination and antimicrobial activity of essential oils towards shigella spp. m aterials and methods: in this study, the antimicrobial and decontamination potentials of essential oils at different concentrations, belonging to plants such as thymus vulgaris, ...
There is a significant need for an effective multivalent Shigella vaccine that targets the most prevalent serotypes. Most Shigella vaccines under development utilize serotype-specific lipopolysaccharides (LPSs) as a major component based on protection and epidemiological data. As vaccine formulations advance from monovalent to multivalent, assays and reagents need to be developed to accurately ...
Shigella species are a common cause of acute diarrheal disease in China. In this study, we characterized the changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010. A total of 5999 Shigella strains were isolated and serotyped from the 302nd Hospital in Beijing. The annual number of Shigella isolates reached a peak (n = 1192; 19.84%) in 1996 and then decreased...
Schneider, Herman (Walter Reed Army Institute of Research, Washington, D.C.), and Stanley Falkow. Characterization of an Hfr strain of Shigella flexneri. J. Bacteriol. 88:682-689. 1964.-A Hfr Shigella flexneri, strain 69, was obtained by terminal marker selection in a cross between Hfr Escherichia coli and S. flexneri. The chromosome of this Hfr Shigella bears gross homology to the E. coli chro...
Acute infectious diarrhea (AID) can cause severe diarrhea which is called shigellosis. Shigella spp. are a group of pathogenic bacteria transmitted through contaminated food [1, 2]. This group of bacteria causes about 165 million cases of diarrhea each year, out of which 163 million occur in developing countries, and 1.5 million in industrialized nations [3]. Shigella species are mainly transmi...
Autophagy, an intracellular degradation process, is increasingly recognized as having important roles in host defense. Interactions between Shigella flexneri and the autophagy machinery were first discovered in 2005. Since then, work has shown that multiple autophagy pathways are triggered by S. flexneri, and autophagic responses can have different roles during Shigella infection. Here, we revi...
A toxin extracted from heat-inactivated, alkaline-treated Shigella flexneri 2a showed biological properties similar to those of Shigella dysenteria 1 toxin. The S, flexneri 2a toxin was lethal to mice, enterotoxic for ileal loops of rabbits, and cytotoxic for HeLa cells. A serological relationship between S. flexneri 2a and S. dysenteriae 1 toxin was shown with cross neutralization tests.
Shigella spp. are known primarily as a cause of bacillary dysentery. However, in an initial phase, numerous patients exhibit watery diarrhea that may or may not be followed by dysentery. New virulence factors associated with the species of Shigella have recently been described. These are enterotoxins 1 and 2 of Shigella (ShET-1 and ShET-2, respectively). The aim of the present study was to dete...
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