scid disorder is major failure of the immune system, usually genetic. the aim of this study was on mutations detection of rag1, rag2, and il7rg genes in scid cases. mutation detection was performed by pcr sequencing. our results  indicated  that 13  mutations  were found  through  cases which  include 4 mutations in il7r gene (t661i, i138v, t56a, c57w), 7 mutations in rag1 (w896x, w204r, m324v,...

introduction bacillus calmette-guérin (bcg) vaccine, a live attenuated mycobacterium bovis strain, is administrated to all newborn infants in endemic regions according to the current world health organization (who) recommendation. case presentation we report a 10-month-boy who was a known case of severe combined immunodeficiency (scid) admitted with multi-focal fusiform painful swelling in his ...

primary immunodeficiencies constitute a group of highly complex congenital disorders most of which are characterized by a very poor prognosis. allogeneic hematopoietic stem cell transplantation (hsct) has become an established curative treatment approach in many of these disorders, which may be permanently corrected. in this presentation basic and practical aspects of hsct are presented, with a...

the (bacille calmette-gue´rin) bcg is widely practiced in many countries in pediatric group and is a part of routine vaccination program at birth in ir. iran for prophylaxis against tuberculosis, but its efficacy is a matter of debate in different geographic and ethnic regions. adverse reactions induced by bcg vaccination ranges from bcg adenitis, osteitis, and cold abscess at vaccination site ...

Lymphocytes residing in the intestinal epithelium are exclusively T cells and account for one of the largest collection of T cells in the organism. However, their function remains obscure. We and others have shown that the development of intestinal intraepithelial T cells is compromised in mutant mice prone to chronic intestinal inflammation. These results led us to directly assess their role i...

Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. These unique findings may be related to the nature of the immunodeficiency in th...

Two patients with severe combined immunodeficiency and enterovirus infections were successfully treated with pleconaril. There were no adverse affects.