introduction: severe acquired aplastic anemia (saa) is a rare disease and matched related hematopoietic stem cell transplantation (hsct) is the treatment of choice especially in pediatric patients. immunosuppressive therapy is the alternative treatment in patients who do not have a donor. we retrospectively analyzed patients who received allogeneic hsct at our institution. methods: between 1991...

UNLABELLED Aplastic anemia is a clonal disease of stem cell characterized by peripheral blood pancytopenia with hypocellular bone marrow. In most cases acquired aplastic anemia is an autoimmune, T-cell mediated disease (hematopoiesis is mediated by a population of CD8+ T-cells which produce inhibitory cytokines - TNF-alpha, IFN-gamma, IL-6 which suppress hematopoiesis by affecting the mitotic c...

Aplastic Anemia 11-18 Outcome of patients with acquired aplastic anemia given first line bone marrow transplantation or immunosuppression treatment in the last decade: a report from the European Group for Blood and Marrow Transplantation Anna Locasciulli, Rosi Oneto, Andrea Bacigalupo, Gerard Socié, Elisabeth Korthof, Albert Bekassy, Hubert Schrezenmeier, Jakob Passweg, Monika Führer, on the be...

9. Zhang F, Zhang L, Jing L, et al. High-dose cyclophosphamide compared with antithymocyte globulin for treatment of acquired severe aplastic anemia. Exp Hematol. 2013;41(4):328-334. 10. Bhatnagar N, Wynn R, Velangi M, et al. Upfront matched and mismatched unrelated transplantation in paediatric aplastic anemia: a United Kingdom multicenter retrospective experience. In: BMT ed. EBMT annual meet...

Aplastic anemia is a condition in which the hematopoietic stem cells fail to function adequately leading to peripheral pancytopenia. When the cytopenia is severe, patients require intensive support with blood products and broad spectrum antibiotics, and without definitive treatment, most will eventually die of infections or bleeding. Over the past 4 decades, however, these once uniformly fatal ...

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