نتایج جستجو برای: serum myostatin

تعداد نتایج: 306461  

2014
Der-Sheng Han Yu Chu-Su Chih-Kang Chiang Fen-Yu Tseng Ping-Huei Tseng Chi-Ling Chen Kwan-Dun Wu Wei-Shiung Yang Bridget Wagner

AIMS Myostatin is a negative regulator of skeletal muscle mass and may also modulate energy metabolism secondarily. We aim to investigate the relationship between serum myostatin and the metabolic variables in diabetic (DM) and non-diabetic subjects. MATERIALS AND METHODS A cross-sectional study recruiting 246 consecutive DM patients and 82 age- and gender-matched non-diabetic individuals at ...

2017
Hiroki Nishikawa Hirayuki Enomoto Akio Ishii Yoshinori Iwata Yuho Miyamoto Noriko Ishii Yukihisa Yuri Kunihiro Hasegawa Chikage Nakano Takashi Nishimura Kazunori Yoh Nobuhiro Aizawa Yoshiyuki Sakai Naoto Ikeda Tomoyuki Takashima Ryo Takata Hiroko Iijima Shuhei Nishiguchi

BACKGROUND We aimed to elucidate the relationship between serum myostatin levels and other markers including skeletal muscle mass and to investigate the influence of serum myostatin levels on survival for patients with liver cirrhosis (LC). METHODS A total of 198 LC subjects were analysed in this study. Myostatin levels were measured using stored sera. We retrospectively investigated the rela...

Journal: :The Journal of reproduction and development 2006
Tohru Hosoyama Keitaro Yamanouchi Masugi Nishihara

Myostatin, also known as GDF-8 (Growth/Differentiation Factor-8), is a member of the TGF-beta superfamily that negatively regulates skeletal muscle mass in mammals. Mutation of the myostatin gene in mice, cattle, and humans causes a massively developed skeletal muscle, characterized by muscle hypertrophy and hyperplasia. Although myostatin is predominantly expressed in skeletal muscle tissue, s...

2013
Astrid Breitbart Gesine M. Scharf David Duncker Christian Widera Jens Gottlieb Arndt Vogel Sebastian Schmidt Gudrun Brandes Hans-Gert Heuft Ralf Lichtinghagen Tibor Kempf Kai C. Wollert Johann Bauersachs Joerg Heineke

BACKGROUND Myostatin is a muscle derived factor that functions as a negative regulator of skeletal muscle growth. Induction of myostatin expression was observed in rodent models of muscle wasting and in cachectic patients with cancer or pulmonary disease. Therefore, there is an increasing interest to use serum myostatin as a biomarker. METHODS We established an immunoradiometric sandwich assa...

Journal: :Journal of sports science & medicine 2004
Darryn S Willoughby Lemuel Taylor

The present study determined the effects of concentric and eccentric muscle actions on the contents of serum myostatin and follistatin-like related gene (FLRG). Eight untrained males performed one exercise bout with each leg, separated by three weeks. One bout consisted of 7 sets of 10 repetitions of eccentric muscle actions of the knee extensors at 150% of the concentric 1-RM while the other b...

2013
György Szláma Mária Trexler László Patthy

Myostatin, a negative regulator of skeletal muscle growth, is produced from myostatin precursor by multiple steps of proteolytic processing. After cleavage by a furin-type protease, the propeptide and growth factor domains remain associated, forming a noncovalent complex, the latent myostatin complex. Mature myostatin is liberated from latent myostatin by bone morphogenetic protein 1/tolloid pr...

Abbas Ali Gaeini, Masomeh Hannani, Mohammad Hemmatinafar, Ramin Shabani,

Introduction: Myostatin regulates skeletal muscle mass and adipogenesis, but serum response to continuous and discontinuous exercises training it has not been studied in menopause and menstrual groups of women. The purpose of this study was to investigate the serum response of myostatin, insulin and glucose to use four different aerobic exercises training in menopause and menstrual groups of wo...

2014
Hui J. Zhu Hong B. Yang Xiang Q. Wang Hui Pan Dian X. Zhang Nai S. Li Lin J. Wang Feng Y. Gong

Objective: Myostatin has recently been proposed as an important factor that not only regulates skeletal muscle mass, but also body fat mass. The aim of our study is to explore serum myostatin levels in overweight patients and its association with metabolic-related characteristics. Methods: 40 overweight patients and 40 normal weight controls were recruited, and serum myostatin were measured by ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1998
N F Gonzalez-Cadavid W E Taylor K Yarasheski I Sinha-Hikim K Ma S Ezzat R Shen R Lalani S Asa M Mamita G Nair S Arver S Bhasin

Myostatin, a member of the transforming growth factor-beta superfamily, is a genetic determinant of skeletal muscle growth. Mice and cattle with inactivating mutations of myostatin have marked muscle hypertrophy. However, it is not known whether myostatin regulates skeletal muscle growth in adult men and whether increased myostatin expression contributes to wasting in chronic illness. We examin...

2017
Pasquale Esposito Edoardo La Porta Marta Calatroni Maria Antonietta Grignano Samantha Milanesi Daniela Verzola Yuri Battaglia Marilena Gregorini Carmelo Libetta Giacomo Garibotto Teresa Rampino

Background. In this study we investigated the relevance of myostatin and Hepatocyte Growth Factor (HGF) in patients undergoing hemodialysis HD and the influence of different HD modalities on their levels. Methods. We performed a prospective crossover study in which HD patients were randomized to undergo 3-month treatment periods with bicarbonate hemodialysis (BHD) followed by online hemodiafilt...

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