background: the sertoli cells in the testis create unique and safe environment to protect seminiferous tubules from auto antigens and invading pathogens. these cells produce the survival factor of the blood-testis barrier and produce special materials such as androgen binding proteins and contribute to the coordinated action of spermatogenesis. given that the sertoli cells play an essential rol...

background: sertoli cells play a pivotal role in creating microenvironments essential for spermatogonial stem cells (sscs) self-renewal and commitment to differentiation. maintenance of sscs and or induction of in vitro spermiogenesis may provide a therapeutic strategy to treat male infertility. objective: this study investigated the role of luekemia inhibitory factor (lif) on the propagation o...

background: the impact of cadmium (cd) on male infertility may be related to the interaction with metal-binding proteins known as metallothioneins (mts). trace elements like zinc (zn) have protective effects on testicular damage induced by cd. objective: we determined the effect of zn and low-dose cd pre-treatment on the expression of mt1 and mt2 genes on testicular sertoli cells. materials and...

background: zinc (zn) as an important trace element is essential for testicular development and spermatogenesis. molecular mechanism of zn action in the reproductive system may be related to metal binding low-molecular weight proteins, metallothioneins (mt). our objective was to determine the effect of zn on two important isoforms of mt, mt1m and mt1g genes expression on testicular sertoli cell...

introduction: morphology and ultra-structure of myoid and sertoli cells were studied in patients with non-obstructive azoospermia who were admitted to testicular sperm extraction (tese) and intracytoplasmic sperm injection (icsi), by transmission electron microscopy (tem). materials and methods: 12 biopsies of testicular tissues from patients with non-obstructive azoospermia referred to royan i...

spermatogonial stem cells (sscs) maintain spermatogenesis throughout life in the male. maintenance of sscs and induction of spermiogenesis in vitro may provide a therapeutic strategy to treat male infertility. this study investigated in vitro differentiation of mouse sscs in presence or absence of sertoli cells, hormones and vitamins. spermatogonial populations were enriched from testes of 4-6 ...

Background Sertoli cells located in seminiferous tubular basement membrane and surrounds different types of germ cell and they were only somatic cell type that directly contacts germ cells. These cells have Several role like support activities, nutrition of germ cells.During spermatogenesis, expression of SOX3 is necessary for differentiation of spermatogonia A. SOX3 is a transcription factor, ...

  Objective(s): Sertoli cells support in vivo germ cell production; but, its exact mechanism has not been well understood. The present study was designed to analyze the effect of Sertoli cells in differentiation of mouse embryonic stem cells (mESCs) to germ cells.   Materials and Methods: A fusion construct composed of a Stra8 gene promoter and the coding region of enhanced green fluorescence p...

objective(s): sertoli cells support in vivo germ cell production; but, its exact mechanism has not been well understood. the present study was designed to analyze the effect of sertoli cells in differentiation of mouse embryonic stem cells (mescs) to germ cells.   materials and methods: a fusion construct composed of a stra8 gene promoter and the coding region of enhanced green fluorescence pro...

Background: Novel roles for the interaction of cardiotonic steroids to Na+/K+-ATPase have been established in recent years. The aim of the present study was to investigate the intracellular signaling events downstream the action of ouabain on Na+/K+-ATPase in Sertoli cell obtained from immature rats. Treatment of Sertoli cells with ouabain (1 μM) induced a rapid and transient increase in the ex...