stabilized Ag Nanoparticles (NPs) were synthesized using Lee-Meisel method under three different conditions in an oil bath. UV-Vis spectroscopy of the Ag NPs showed a Localized Surface Plasmon (LSP) band around 430 nm, indicating Ag NPs had a size range around 40 nm. To fabricate a surface Enhanced Raman Spectroscopy (SERS) substrate, LSP properties of Ag NPs was employed with the goal of detec...

Colorectal cancer (CRC) is one of the leading cancers in the world and early-screening is still the best method of cancer patient survival. However, colonoscopy as the current gold standard is not without flaws and an emerging technique called surface-enhanced Raman spectroscopy (SERS) coupled with machine learning is a possible candidate that could be applied in parallel with colonoscopy. This...

Colorectal cancer (CRC) is one of the leading cancers in the world and early-screening is still the best method of cancer patient survival. However, colonoscopy as the current gold standard is not without flaws and an emerging technique called surface-enhanced Raman spectroscopy (SERS) coupled with machine learning is a possible candidate that could be applied in parallel with colonoscopy. This...

This article describes recent developments in the field of surface-enhanced Raman scattering (SERS) research. It begins with the early history of SERS as the first SERS spectrum was obtained from an electrochemical system of pyridine molecule adsorbed on roughened silver electrode, which led to the discovery of the SERS effect in the mid-1970s. The article also illustrates the various aspects o...

A new high-performance surface-enhanced Raman scattering (SERS) substrate with extremely high SERS activity was produced. This SERS substrate combines the advantages of Au film over nanosphere (AuFON) substrate and Ag nanoparticles (AgNPs). A three order enhancement of SERS was observed when Rhodamine 6G (R6G) was used as a probe molecule to compare the SERS effects of the new substrate and com...

surface-enhanced raman spectroscopy (sers) is a promising tool in the analytical science because it provides good selectivity and sensitivity without the labeling process required by fluorescence detection. this technique consists of locating the target analyte on nanometer range of roughed au-nanoparticles. the presence of the metal nanoparticles provides a tremendous enhancement to the result...

Nanoparticle surface enhanced Raman scattering (SERS) tags have attracted interest as labels for use in a variety of applications, including biomolecular assays. An obstacle to progress in this area is a lack of standardized approaches to compare the brightness of different SERS tags within and between laboratories. Here we present an approach based on binding of SERS tags to beads with known b...