Curcumin exhibits both cancer- preventive activity and growth inhibitory effects on several neoplastic cells including human colon cancer. Serotonin and its receptors have also been implicated in tumor development. This study investigated the effect of ritanserin, a selective serotonin 5HT2A receptor antagonist, alone and in combination with curcumin on colorectal cancer cell lines. Result...

curcumin exhibits both cancer- preventive activity and growth inhibitory effects on several neoplastic cells including human colon cancer. serotonin and its receptors have also been implicated in tumor development. this study investigated the effect of ritanserin, a selective serotonin 5ht2a receptor antagonist, alone and in combination with curcumin on colorectal cancer cell lines. results sho...

This study sought to determine whether depressive symptoms and/or platelet serotonin receptor (5HT2A) density are associated with increased platelet activation (PA) found among smokers. Flow cytometric detection of PA was used to study 36 smokers and 16 nonsmokers, aged 18 to 48 years. Subjects were tested at baseline and after either smoking 2 cigarettes (smokers) or a similar resting interval...

UNLABELLED Many inhaled anesthetics block the in vitro effect of the excitatory neurotransmitter serotonin on the 5-HT2A receptor, supporting the view that this receptor might mediate the capacity of inhaled anesthetics to produce immobility during noxious stimulation (i.e., would underlie MAC, the minimum alveolar concentration required to suppress movement in response to a noxious stimulus in...

Background: Excessive bleeding occurs when anti-thrombotic drugs for patients with thrombotic risk are administered in the context of surgical operations and trauma. Purpose: Analysis of data from the published literature on the mechanism of occlusive arterial thrombosis and evaluation of the most likely drug intervention that might circumvent this problem. Results: Activation of platelets by h...

An enquiry into the lack of attention awarded to serotonin antagonism in the treatment of arterial thrombosis revealed that the mode of action of serotonin and its platelet receptor antagonists was an action upon thrombus growth, and not, as with other anti-platelet drugs upon the initiation of thrombosis. This lack of effect could explain why this approach has been considered not to be effecti...

This article highlights some important aspects of the pathophysiology of coronary artery disease, namely: • The distribution of lesions within the arterial tree at sites of low wall shear stress. • The potential role of low flow-mediated arterial dilatation at sites of low wall stress. • Low flow-mediated dilatation leads to low nitric oxide production by the arterial endothelium and consequent...

OBJECTIVE Studies have suggested that sex differences in endothelial function in part account for the lower incidence of cardiovascular disease in premenopausal women compared with men. Less is known about the role of smooth muscle. We hypothesized that signaling mechanisms that regulate calcium sensitivity in vascular muscle also play a role in determining sex differences in contractile functi...

Additional somatosensory contact of preterm human infants improves a variety of developmental assessment scores, but less is known about its lasting consequences. In rodents, maternal contact may influence the programming of juvenile social play behavior. Therefore, we used a paradigm where we can control the levels of somatosensory contact associated with maternal care. We find that additional...

Page 1 of 2 (page number not for citation purposes) Recently, Beretta and colleagues [1] reported a protective association of the serotonin 5-HT2A receptor gene polymorphism His452Tyr (C+1354T, rs6314) with systemic sclerosis (SSc) in an Italian population. 5HT2A accounts for most vasoconstrictive and platelet aggregation due to serotonin activity [2]. Beretta and colleagues also demonstrated t...