seroresponse to the full three - dose of the hepatitis b vaccine (engcrix-b) was studied in 138 medical and paramedical staff from tehran. the vaccine was found to be highly immunogenic. seroconversion rales, scroprotecthn rates and geometric mean titer were found to be 98.$%, 90% and 902.$ mlu/ml, respectively. tills is the first report of sero-rcsponse in normal iranian subjects to the hepati...

PURPOSE Lamivudine is known to be very effective in suppressing hepatitis B virus replication and virus induced necroinflammation. The aim of this study was to evaluate lamivudine therapy efficacy, predictive factors, breakthrough, prevalence of YMDD mutation, and relapse rate in Korean children with chronic hepatitis B. MATERIALS AND METHODS Between August 1999 and February 2005, 60 children...

BACKGROUND HBeAg seroconversion is an important intermediate outcome in HBeAg-positive chronic hepatitis B (CHB) patients. This study aimed to compare the effect of nucleos(t)ide analogs (NAs) on HBeAg seroconversion in treating CHB with lamivudine, adefovir, telbivudine, entecavir, and tenofovir. METHODS Network meta-analysis of NA treatment-induced HBeAg seroconversion after 1-2 years of tr...

BACKGROUND AND AIM Clinical data on spontaneous hepatitis B e antigen (HBeAg) seroconversion and acute exacerbation of chronic hepatitis B (CHB) virus infection from large population studies are lacking. In the present study we examined the clinical features and significance of HBeAg seroconversion and acute exacerbation in 3063 Chinese CHB patients. METHODS Clinical assessment, liver biochem...

OBJECTIVE To determine the prevalence, incidence, and persistence of positivity for antibodies to hepatitis C virus (anti-HCV) and the potential for sexual transmission of the virus. DESIGN A cohort analysis covering 1981-9 comparing estimated cumulative incidences of and seroconversion rates for anti-HCV with those of hepatitis B core antibody (anti-HBc) and antibodies to the human immunodef...

The prevalence of hepatitis C virus (HCV) infection in hemodialysis units (HD) is higher than among normal population. Seroconversion was included in many previous studies which constitute a great problem against infection control policies. The aim of this study was to evaluate seroconversion rate and the effect of isolation of hepatitis C positive patients as infection control method. This is ...

OBJECTIVE This study explores the trends and associated factors of HIV, hepatitis C virus (HCV) and syphilis seroconversion among Chinese methadone maintenance treatment (MMT) clients over a follow-up period of up to 7 years. DESIGN Drug users from 14 MMT clinics in Guangdong Province were recruited during 2006-2014. Participants were seronegative with at least one HIV, HCV or syphilis infect...

background: canine visceral leishmaniasis (cvl) is not only an emerging veterinary concern but also a public health threat in endemic areas. the aim of this study was to assess the efficacy, immunogenicity and safety of two doses of aluminum hydroxide (alum) precipitated leishmania major (alum-alm) mixed with bcg plus imiquimod against cvl. methods: a total of 560 ownership dogs were serologica...

BACKGROUND Prevalence of total antibodies against core antigen (anti-HBc) of hepatitis B virus (HBV) is greater in longer dialysed patients, but there are no data indicating a relationship between the higher seroconversion rate to anti-HBc positivity and longer renal replacement therapy (RRT) vintage prior to seroconversion. Our aim was to evaluate the association between RRT duration and seroc...