Purpose: To explore the effects of single-nucleotide polymorphisms (SNP) on pancreatic cancer risk and overall survival (OS). ExperimentalDesign: The germ lineDNAof 531pancreatic cancer cases and305healthy controls froma hospital-based studywas genotyped at SNPs previously reported to be associatedwith pancreatic cancer risk or clinical outcome.We analyzedputative risk SNPs for replication of t...

Purpose: Tumor hypoxia is associated with a poor prognosis, hypoxia modification improves outcome, andhypoxic status predicts benefit from treatment. Yet, there is nouniversalmeasureof clinical hypoxia. The aim of this study was to investigate whether a 26-gene hypoxia signature predicted benefit from hypoxiamodifying treatment in both cancer types. ExperimentalDesign: Sampleswere available fro...

abstract background iron overload is a major problem in patients with major thalassemia. an effective and safe iron chelator protocol with high compliance rate plays an important role in treatment of these patients. this study was done to assess the efficacy and safety of the sequential deferoxamine and deferasirox protocol in major thalassemia patients in khuzestan province, iran. material and...

This study aims to determine the level of effectiveness thecooperative learning model type TAI "Team AssistedIndividulization" and STAD "Student Teams AchievementDivisions" as a in improving critical thinking ofelementary school students class V science subjects. Thisexperimental research was form Quasi ExperimentalDesign. The design used is quasi-experimental researchusing nonequivalent contro...

thechah nimeh reservoirs of sistan is as one of the main water sources of zabol city used for drinking, agriculture, industry and livestock purposes. this study aimed to determine the contribution of the natural and concentration factors of heavy metals such as cd, pb and cu in sediment of chah nimeh of sistan. the concentrations of heavy metals in surface sediments were studied in six stations...

we analyze a sequential decision making process, in which at each stepthe decision is made in two stages. in the rst stage a partially optimalaction is chosen, which allows the decision maker to learn how to improveit under the new environment. we show how inertia (cost of changing)may lead the process to converge to a routine where no further changesare made. we illustrate our scheme with som...

abstract uranium as a natural radioactive heavy metal widely disperses throughout the earth's crust. in many cases, the natural abundance has been re-distributed due to anthropogenic activities, resulting in radionuclide contamination in groundwater and surface soil. uranium through the plant uptake can enter the chain. the degree of speciation of radio nuclides in soils in areas with differing...

fifty street dust samples were collected from southern and eastern parts of tehran, the capitalof iran. samples were collected during summer under dry and stable weather conditions. total concentrationsof copper (cu), cadmium (cd), lead (pb), chromium (cr), nickel (ni), zinc (zn), iron (fe), manganese (mn)and lithium (li) were determined. ten samples were then selected for characterization, met...