نتایج جستجو برای: sepsc

تعداد نتایج: 70  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Jessica A Fawley Mackenzie E Hofmann Michael C Andresen

Action potentials trigger synaptic terminals to synchronously release vesicles, but some vesicles release spontaneously. G-protein-coupled receptors (GPCRs) can modulate both of these processes. At cranial primary afferent terminals, the GPCR cannabinoid 1 (CB1) is often coexpressed with transient receptor potential vanilloid 1 (TRPV1), a nonselective cation channel present on most afferents. H...

Journal: :Molecular Pain 2009
Ji-Hyeon Song Eun-Sung Park Sang-Mi Han Seung-Ro Han Dong-Kuk Ahn Dong-Ho Youn

Group I mGluRs (mGluR1 and 5) pre- and/or postsynaptically regulate synaptic transmission at glutamatergic synapses. By recording spontaneous EPSCs (sEPSCs) in the spinal trigeminal subnucleus oralis (Vo), we here investigated the regulation of glutamatergic transmission through the activation of group I mGluRs. Bath-applied DHPG (10 microM/5 min), activating the group I mGluRs, increased sEPSC...

Journal: :Journal of neurophysiology 2014
Tally M Largent-Milnes Deborah M Hegarty Sue A Aicher Michael C Andresen

Trigeminal sensory afferent fibers terminating in nucleus caudalis (Vc) relay sensory information from craniofacial regions to the brain and are known to express transient receptor potential (TRP) ion channels. TRP channels are activated by H(+), thermal, and chemical stimuli. The present study investigated the relationships among the spontaneous release of glutamate, temperature, and TRPV1 loc...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Silvia Marinelli Vincenzo Di Marzo Nicola Berretta Isabel Matias Mauro Maccarrone Giorgio Bernardi Nicola B Mercuri

Growing evidence regarding the function of vanilloid receptor-1 (VR1) in the brain suggests potential central roles of this receptor, previously described to occur primarily in peripheral sensory neurons. In the present study, we used electrophysiological and biochemical techniques to investigate the function and the endogenous stimulation of VR1 in dopaminergic neurons of the substantia nigra ...

Journal: :Anesthesia and analgesia 2004
Rainer Haseneder Jörge Kurz Hans-Ulrich U Dodt Eberhard Kochs Walter Zieglgänsberger Michaela Scheller Gerhard Rammes Gerhard Hapfelmeier

UNLABELLED The minimum alveolar concentration (MAC) of a volatile anesthetic defines anesthetic potency in terms of a suppressed motor response to a noxious stimulus. Therefore, the MAC of an anesthetic might in part reflect depression of motor neuron excitability. In the present study we evaluated the effect of isoflurane (ISO) on neurons in the substantia gelatinosa driven synaptically by put...

2007
Jian Yang Caroline Wetterstrand Roland S.G. Jones

We have shown that a number of anticonvulsant drugs can reduce glutamate release at synapses in the rat entorhinal cortex (EC) in vitro. We have also shown that presynaptic NMDA receptors (NMDAr) tonically facilitate glutamate release at these synapses. In the present study we determined whether, phenytoin, gabapentin and felbamate may reduce glutamate release by blocking the presynaptic NMDAr....

2017
Mackenzie E Hofmann Michael C Andresen

The recycling of vesicle membrane fused during exocytosis is essential to maintaining neurotransmission. The GTPase dynamin is involved in pinching off membrane to complete endocytosis and can be inhibited by dynasore resulting in activity-dependent depletion of release-competent synaptic vesicles. In rat brainstem slices, we examined the effects of dynasore on three different modes of glutamat...

Journal: :iranian journal of basic medical sciences 0
mitra yousefpour department of physiology, faculty of medicine, artesh university of medical science, tehran, iran nima naderi department of pharmacology and toxicology, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran fereshteh motamedi neuroscience research center, shahid beheshti university of medical science, tehran, iran department of physiology, faculty of medicine, shahid beheshti university of medical science, tehran, iran

objective(s): opioids and cannabinoids are two important compounds that have been shown to influence the activity of magnocellular neurons (mcns) of supraoptic nucleus (son). the interaction between opioidergic and cannabinoidergic systems in various structures of the brain and spinal cord is now well established, but not in the mcns of son. materials and methods: in this study, whole cell patc...

Journal: :The Journal of physiology 2006
Marco Canepari David Ogden

Type 1 metabotropic glutamate receptors (mGluR1) in Purkinje neurones (PNs) are important for motor learning and coordination. Here, two divergent mGluR1 Ca2+-signalling pathways and the associated membrane conductances were distinguished kinetically and pharmacologically after activation by 1-ms photorelease of L-glutamate or by bursts of parallel fibre (PF) stimulation. A new, mGluR1-mediated...

Journal: :The Journal of General Physiology 2002
Hajime Hirasawa Richard Shiells Masahiro Yamada

The role of group III metabotropic glutamate receptors (mGluRs) in photoreceptor-H1 horizontal cell (HC) synaptic transmission was investigated by analyzing the rate of occurrence and amplitude of spontaneous excitatory postsynaptic currents (sEPSCs) in H1 HCs uncoupled by dopamine in carp retinal slices. Red light steps or the application of 100 microM cobalt reduced the sEPSC rate without aff...

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