results the present study revealed that the sobt and sop extracts showed in vitro bactericidal activity against gram-positive and gram-negative bacteria. furthermore, administration of sobt and sop increased the rats’ survival rates by 66.7% and 83.33%, respectively, as compared to the untreated clp-septic rats. treatment of the clp-septic rats with sobt and sop significantly alleviated alterat...

Sleep has been observed in several invertebrate species, but its presence in marine invertebrates is relatively unexplored. Rapid-eye-movement (REM) sleep has only been observed in vertebrates. We investigated whether the cuttlefish Sepia officinalis displays sleep-like states. We find that cuttlefish exhibit frequent quiescent periods that are homeostatically regulated, satisfying two criteria...

Obesity is a global health problem. It is also known to be a risk factor for the development of metabolic disorders, type 2 diabetes, systemic hypertension, cardiovascular disease, dyslipidemia, and atherosclerosis. In this study, we elucidated that Buddleja officinalis Maximowicz extract significantly inhibited lipid accumulation during 3T3-L1 adipocyte differentiation. Furthermore, Buddleja o...

Polar lipids of the cephalopods Eledone moschata, Sepia officinalis and Todarodes sagittatus mantle, represent 50.5%, 66.1% and 74.2% of wet tissue respectively. On the other hand the polar lipids of these three species of cephalopods constitute of 80.8%, 94.8% and 93.7% of phospholipids, respectively. The main phospholipids identified were phosphatidylcholine (52.2, 51.3 and 58.4% of total pho...

BACKGROUND Sepsis remains a major problem for both scientists and clinicians. Cecal ligation and puncture (CLP) is considered the gold standard for animal models of sepsis. The undesirable side effects of certain antibiotics have forced scientists to discover new, natural, and safe antimicrobial agents, such as cephalopods, which are known to display significant antimicrobial activity. OBJECT...

Sepia ink, a black suspension of melanin granules, is multifunctional marine bioactive material. The present study aims to evaluate the ameliorative effect ink extract (IE) cuttlefish (Sepia officinalis) during high dosage administration FA in rats. Kidney injury induced by single oral dose (250 mg /kg). Eighteen male Wistar albino rats were control, group, and FA+ IE group (250mg/kg). showed s...

We tested color perception based upon a robust behavioral response in which cuttlefish (Sepia officinalis) respond to visual stimuli (a black and white checkerboard) with a quantifiable, neurally controlled motor response (a body pattern). In the first experiment, we created 16 checkerboard substrates in which 16 grey shades (from white to black) were paired with one green shade (matched to the...

Around the posterior pallial vessels in Sepia officinalis a ball-shaped structure has been found which is evidently an accessory organ of the circulatory system. It has also been observed in Loligo forbesi, but not in the two decapods examined, Eledone cirrhosa and Octopus vulgaris. The following description is based on the study of Sepia. In an account of the nerves supplying the accessory org...

This article comprises an up-dated review of the processes influencing the distribution and abundance of common cuttlefish Sepia officinalis, the interactions between the species and the main parameters of the environment in which it lives and its trophic, demographic and behavioural ecology.

The ink gland of the cuttlefish Sepia officinalis has traditionally been regarded as a convenient model system for investigating melanogenesis. This gland has been shown to contain a variety of melanogenic enzymes including tyrosinase, a dopachrome-rearranging enzyme and peroxidase. However, whether and to what extent these enzymes co-localize in the melanogenic compartments and interact is an ...