BACKGROUND Oxidative stress induced tissue damage might be the major cause for diabetes mellitus and its associated complications. The management of such oxidative stress is the biggest challenge over the decade. The main objective was to analyze the protective effect of ethanolic extract of Senna alata L leaves on enzymatic and nonenzymatic antioxidant systems of hepatic and renal tissues in S...

Ethanolic extracts of Canarium schweinfurthii stem bark and Senna alata leaf, and aqueous extract of unripe Carica papaya fruit, at two different doses (150, 400 mg/kg), were evaluated for antihyperglycaemic and hypolipidemic effects on alloxan-induced diabetic rats following daily oral administration for 28 days. While antihyperglycaemic effect was lacking in Senna alata, it was persistent (P<...

Background: Senna alata (S. alata) has numerous pharmacological activities including anti-lipogenic effect in highfat diet (HFD)-induced obese mice. The present study investigated the effect of Senna alata (S. alata) leaf extracts on the regulation of abnormal glucose metabolism in HFD-induced obese mice. Methods: Male ICR mice were induced to become obese by being fed a HFD (45 kcal% lard fat)...

The methanolic extract and fractions (ethyl acetate and butanol) of Senna alata, a major medicinal plant used in traditional medicine in Nigeria were evaluated for possible hepatoprotective activity against carbon tetrachloride (CCl4) – induced hepatotoxicity in wistar albino rats. Phytochemical screening indicates the presence of tannins, phlobatannins, alkaloids, anthraquinones, flavonoids, c...

Efficacy of seven fungicides and seven plant extracts were evaluated against two pathogenic species of fungi isolated from Senna alata L. in vitro. The isolated fungi were Colletotrichum gloeosporioides (Penz.) Sacc. and Pestalotiopsis guepinii (Desm.) Stay. Seven fungicides Acrobate MZ, Bavistin 50 WP, Indofil M-45, MC Sulphur 80 WP, Ridomil MZ Gold, Sulcox 50 WP and Tall 25 EC at 100, 200, 30...

A microplate assay and a thin-layer chromatography (TLC) "in situ" assay based on the Ellman assay was used to screen for acetylcholinesterase inhibitors from ethyl acetate and methanol extracts of Brazilian medicinal plants of families that, according to the literature, have traditional uses that might be connected with acetylcholinesterase inhibition. Eighteen species belonging to Convolvulac...

background: the abortifacient claim of senna alata (s. alata) was scientifically validated recently with alkaloids speculated to be the bioactive agent. this speculation is yet to be substantiated or refuted by scientific evidence. the present study was aimed to investigate the pregnancy terminating effects of the alkaloids from s. alata leaves. methods: twenty four pregnant rats (143.99±1.21 g...

The leaves of 10 Cassia species (Leguminosae), cultivated in Nigeria, were assayed spectrophotometrically for combined anthraquinone content and also pharmacologically for their laxative properties in male albino rats using official senna leaves (Cassia acutifolia Del.) as the reference standard. Leaves of C. podocarpa Guill, and Perr. and of senna had identical laxative potency. The results of...

BACKGROUND Ultraviolet radiation from sunlight induces overproduction of reactive oxygen species (ROS) resulting in skin photoaging and hyperpigmentation disorders. Novel whitening and anti-wrinkle compounds from natural products have recently become of increasing interest. The purpose of this study was to find products that reduce ROS in 14 Thai plant extracts. METHODS To determine total phe...

Proanthocyanidins (PA) in Senna alata leaves were investigated by thiolysis with benzyl mercaptan, LC-MS and NMR and consisted of almost pure propelargonidins with <6% procyanidins, had B-type linkages and a mean degree of polymerisation of three. Epiafzelechin was the major flavan-3-ol subunit (>94%) and epicatechin a minor constituent (6.4%) in residual PA and mainly detected as an extension ...