secreted cytokines of th1 (t-helper)/th2 cells play an important role in the pathogenesis of many diseases. th1 cells secrete predominantly ifn-γ and il-2 which regulate cell-mediated immunity against intracellular pathogens and tumors. in this study, expression of ifn-γ was studied using semiquantitative rt-pcr. in brief, lymphocytes of a healthy donor were stimulated with pha (1μg/106 cell/ml...

Molecular activities can be predicted by Quantitative Structure Activity Relationship (QSAR). Because of the high cost of experiments, the number of drug molecules with known activity is much less than that of unknown, to predict molecular activities utilising unlabelled instances will be an interesting issue. Here, Semi-Supervised Learning (SSL) is introduced and a SSL method, Co-Training is i...

Background: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) provides functional information on the microcirculation in tissues by analyzing the enhancement kinetics which can be used as biomarkers for prostate lesions detection and characterization.Objective: The purpose of this study is to investigate spatiotemporal patterns of tumors by extracting semi-quantitative as well as w...

the efficiency of three statistical models, ahp surface-weighted density bivariate (semi-quantitative models), stepwise multivariate regression and logistic multivariate regression models were compared in chehel-chai watershed in golestan province, iran. in current study the hazard map was prepared according to the top model of landslide hazard map. chehel-chai watershed is located as one of go...

sodium/proton exchangers (nhx) are key players in plant responses to salinity and have a central role in establishing ion homeostasis. nhxs can be localized in tonoplast or plasma membranes, where they exchange sodium ions for protons, resulting in the removal of ions from the cytosol into vacuole or extracellular spaces. in the present study, the expression pattern of the gene encoding na+/h+ ...

introduction: calcium/calmodulin-dependent protein kinase ii (camkii) is highly expressed in the hippocampus, which has a pivotal role in reward-related memories and morphine dependence. methods: in the present study, morphine tolerance was induced in male wistar rats by 7 days repeated morphine injections once daily, and then gene expression profile of α-isoform of camkii (camkiiα) in the hipp...

objective: inhibition of apoptosis may favor the onset and progression of cancer. survivin is an inhibitor of apoptosis that has been considered as a potential marker for diagnostic and/or prognostic of bladder cancer. the survivin protein regulates both cell division and cell death and is overexpressed in the vast majority of human cancers. in this study, the expression pattern and potential p...