the fruit essential oil of ferula gummosa boiss., umbelliferae, which has been used as an antiepileptic remedy in iranian traditional medicine, was evaluated for anticonvulsant activity against experimental seizures. the essential oil had no effect against seizures induced by maximal electroshock. however, it protected mice against pentylenetetrazole-induced tonic seizures. the protective dose ...

Introduction: Epilepsy is the second most common nervous disorder after brain strok. In spite of present anticonvulsant drugs, researchers need to search for drugs with better efficacy and less side effects. Medicinal plants with various natural components so that different properties are suitable field for investigation. In this study, anticonvulsant effect of Lavandula vera DC. and Cuscuta ep...

Introduction: Epilepsy is the second most common nervous disorder after brain strok. In spite of present anticonvulsant drugs, researchers need to search for drugs with better efficacy and less side effects. Medicinal plants with various natural components so that different properties are suitable field for investigation. In this study, anticonvulsant effect of Lavandula vera DC. and Cuscuta ep...

Orexin can increase neuronal excitability and induce epileptic activity. In this study, the effects of suvorexant (orexin receptor antagonist) on pentylenetetrazol (PTZ) and maximal electroshock (MES)-induced seizure were investigated. Mice were divided into 5 groups of six animals each including normal saline (10 ml/kg), diazepam (2 mg/kg) and suvorexant (50, 100 and 200 mg/kg) groups. In PTZ ...

Orexin can increase neuronal excitability and induce epileptic activity. In this study, the effects of suvorexant (orexin receptor antagonist) on pentylenetetrazol (PTZ) and maximal electroshock (MES)-induced seizure were investigated. Mice were divided into 5 groups of six animals each including normal saline (10 ml/kg), diazepam (2 mg/kg) and suvorexant (50, 100 and 200 mg/kg) groups. In PTZ ...

The pharmacological interaction between cannabinoidergic system and vanilloid type 1 (TRPV1) channels has been investigated in various conditions such as pain and anxiety. In some brain structure including hippocampus, CB1 and TRPV1 receptors coexist and their activation produces opposite effect on excitability of neurons. In this study, we tested the hypothesis that TRPV1 channel is involved i...

The pharmacological interaction between cannabinoidergic system and vanilloid type 1 (TRPV1) channels has been investigated in various conditions such as pain and anxiety. In some brain structure including hippocampus, CB1 and TRPV1 receptors coexist and their activation produces opposite effect on excitability of neurons. In this study, we tested the hypothesis that TRPV1 channel is involved i...

Objective: Regarding the anticonvulsant effects of Satureja hortensis (S. hortensis) in Avicenna’s book: canon of medicine; the present study was undertaken to evaluate the anti- eplileptic effects of S. hortensis aqueous and ethanolic aerial part extracts. Furthermore, the mechanisms of their anticonvulsant activities were also evaluated. Materials and Methods: Seizure was induced by Pentylen...

the pharmacological interaction between cannabinoidergic system and vanilloid type 1 (trpv1) channels has been investigated in various conditions such as pain and anxiety. in some brain structure including hippocampus, cb1 and trpv1 receptors coexist and their activation produces opposite effect on excitability of neurons. in this study, we tested the hypothesis that trpv1 channel is involved i...

objective: regarding the anticonvulsant effects of satureja hortensis (s. hortensis) in avicenna’s book: canon of medicine; the present study was undertaken to evaluate the anti- eplileptic effects of s. hortensis aqueous and ethanolic aerial part extracts. furthermore, the mechanisms of their anticonvulsant activities were also evaluated. materials and methods: seizure was induced by pentylent...