separation of ten sedative- hypnotic drugs was performed by rp-hplc using mixed micellar mobile phase. effect of temperature, type and amount of organic modifier in mobile phase on efficiency (n) and asymmetry factor (b/a) showed that, the appropriate conditions for a good separation were 35°c and 7% (v/v) butanol in mobile phase.  variations of selectivity factor versus butanol concentration, ...

The primary use of sedative–hypnotic and anxiolytic drugs is to encourage calmness (anxiolytics or sedatives) or to produce sleep (sedative–hypnotics). All people are subject to states of emotional tension and uneasiness. For otherwise healthy individuals, these occasions are usually sufficiently mild and short that pharmacological intervention is unnecessary. However, at times the symptoms of ...

The present study was undertaken to evaluate Tagara and Jatamansi for certain CNS activities to ascertain the basis for their use as a sedative and hypnotics. The drugs were evaluated for hypnotic and sedative, anti anxiety, anti depressant and anti psychotic activities using standard experimental protocol. The data generated suggests that the test drugs Tagara and Jatamansi have complex CNS ac...

The purpose of this updating manuscript is to briefly describe the profile, clinical use and indication of some of the most used sedative and hypnotic compounds. About 2/3 of all hypnotic prescriptions go to chronic use. Benzodiazepines are among the most prescribed drugs worldwide. Women, elderly, psychiatric and medical disease patients are among chronic users of hypnotics. Zolpidem is now th...

INTRODUCTION There are many common drugs which have significant sedative-hypnotic properties. Alcohol and barbiturates have been discussed separately in this appendix, and their many pharmacological similarities were indicated. Barbiturates are often considered the prototype of sedative-hypnotic drugs; pharmacologically related compounds are frequently identified or discussed in terms of their ...

INTRODUCTION There are many common drugs which have significant sedative-hypnotic properties. Alcohol and barbiturates have been discussed separately in this appendix, and their many pharmacological similarities were indicated. Barbiturates are often considered the prototype of sedative-hypnotic drugs; pharmacologically related compounds are frequently identified or discussed in terms of their ...

INTRODUCTION There are many common drugs which have significant sedative-hypnotic properties. Alcohol and barbiturates have been discussed separately in this appendix, and their many pharmacological similarities were indicated. Barbiturates are often considered the prototype of sedative-hypnotic drugs; pharmacologically related compounds are frequently identified or discussed in terms of their ...

in the present work sedative and hypnotic effects of aqueous extract of aloe vera in rats have been investigated. in order to evaluate the overall hypnotic effects of the aloe vera extract, open field and loss of righting reflex tests were primarily used. the sedative and hypnotic effects of the extract were then confirmed by detection of remarkable raise in the total sleeping time through anal...