background: it has been reported that secreted frizzled-related protein-4 known as an antagonist of wnt signaling pathway plays a role in luteinization process of rodent granulosa cells. the purpose of this study was twofold: 1) to determine whether recombinant human secreted frizzled-related protein-4 (rhsfrp-4) could directly induce terminal differentiation of rat granulosa cells (gcs) and 2)...

introduction: astrocytes, the most abundant glia in the central nervous system, modulate neuronal survival and function. astrocytic functions are mediated by synthesis and secretion of wide ranges of polypeptides through mechanism (s) poorly understood. among these, tgfβs are synthesized and released by the astrocytes. in this study, the involvement of wnt signaling pathway on the synthesis of ...

Animals’ Wnt signaling pathways are highly preserved signal transduction pathways, which play a crucial role in embryogenesis and adult tissue homeostasis. This chapter reviews the three major focusing on some critical proteins Wnt/β-catenin path terms of their evolution act as gateway between extracellular, cytoplasmic, nuclear components to transmit pathways. The Frizzled (FZD) family G-prote...

Secreted frizzled-related protein 1 (sFRP-1) is a secreted protein, belonging to the glycoprotein SFRP family. As modulator of Wnt/β-catenin signalling pathway, sFRP-1 has implications in human cancers and neurologic diseases. If community had access well-characterized anti-sFRP-1 antibodies, reproducibility research would be enhanced. In this study, we characterized 11 commercial antibo...