background: frequent infections is among the most frequent clinical dilemmas for primary care physicians. immunodeficiency disorders are a heterogeneous group of illnesses that predispose patients to the recurrent infections, autoimmunity and malignancies. the aim of this study was to evaluate the clinical and laboratory data collected for the final diagnosis of patients referred with recurrent...

Background: Frequent infections is among the most frequent clinical dilemmas for primary care physicians. Immunodeficiency disorders are a heterogeneous group of illnesses that predispose patients to the recurrent infections, autoimmunity and malignancies. The aim of this study was to evaluate the clinical and laboratory data collected for the final diagnosis of patients referred with recurrent...

Immune deficiencies that develop in previously immunologically intact individuals are called secondary immunodeficiencies; they are a result of diverse external factors (infections, surgery and trauma, malnutrition, drugs) and a number of human diseases, including malignancy, nephrotic syndrome and protein-losing enteropathy. Immunodeficiencies render the host markedly susceptible to viral and ...

common variable immunodeficiency (cvid) is the most common symptomatic primary immunodeficiency disease, predisposing the patients to various tissue involvement and organ damage. here a 16-year-old boy is presented who was referred to our center with cough, dyspnea,cyanosis, and history of recurrent pneumonia. the diagnosis of cvid was made according to reduction all serum immunoglobulin levels...

The International Union of Immunological Societies now recognizes over 430 single gene inborn errors immunity, making the investigation suspected immunodeficiency in children increasingly complex. use immunomodulatory therapies, including biologics, may also cause both transient and permanent secondary immunodeficiency. This review outlines a practical approach to guide paediatric doctors allie...

Primary immunodeficiency diseases are rare hereditary conditions that usually occur at a young age; however, secondary immunodeficiency is acquired due to disease, drug treatment and is increasing in frequency among the population. Although periodontal diseases related to these conditions are secondary to other life threatening manifestations, they are very common and easily detectable by the p...