In this study the influence of azelaic acid (AZA) 20% cream on the sebum excretion rate (SER) of 80 volunteers having mild to moderate acne vulgaris was demonstrated. Absorbent paper and Sebutape were used to collect the sebum and quantification was carried out by direct gravimetric method. It was shown that topical application of AZA creams could reduce the SER and number of acneic lesions...

in this study the influence of azelaic acid (aza) 20% cream on the sebum excretion rate (ser) of 80 volunteers having mild to moderate acne vulgaris was demonstrated. absorbent paper and sebutape were used to collect the sebum and quantification was carried out by direct gravimetric method. it was shown that topical application of aza creams could reduce the ser and number of acneic lesions as ...

BACKGROUND Propionibacterium acnes is a major contributing factor to the inflammatory component of acne. The interaction of P. acnes with keratinocytes leads to an innate immune response via activation of toll-like receptors (TLR2, TLR4) resulting in the production and secretion of pro-inflammatory mediators. SIG1273, an isoprenylcysteine small molecule modulates inflammatory signaling pathways...

To investigate androgen effects on the skin pilosebaceous unit, we studied 21 male-to-female transsexuals and 17 female-to-male transsexuals receiving cross-sex hormones. At baseline and after 4, 8, and 12 months, hair growth was evaluated by the Ferriman-Gallwey score; acne by the Leeds classification; hair growth rate, density, and shaft diameter by image analysis; and sebum production by Seb...

The skin acts as an endocrine organ capable of hormone production and response. Moreover, conditions such acne, hirsutism, androgenetic alopecia, hidradenitis suppurativa clinically improve with anti-androgen therapies. Despite their importance, we have incomplete understanding the composition hormones produced by skin. In our current study, characterized hormonal landscape across anatomical si...

A NMR spectroscopic method is described that enables the quantitation of specific lipid classes and components, independent of fatty acid composition. We demonstrate this method for measuring cholesterol, squalene, and pools of sterol esters, wax esters (WEs), and triglyceride (TG) components in sebum and meibum. When 600 MHz NMR equipment is used in conjunction with highly sensitive cryogenica...

Sebum is a complex lipid mixture that is synthesized in sebaceous glands and excreted on the skin surface. The purpose of this study was the comprehensive detection of the intact lipids that compose sebum. These lipids exist as a broad range of chemical structures and concentrations. Sebum was collected with SebuTape(TM) from the foreheads of healthy donors, and then separated by HPLC on a C8 s...

BACKGROUND Polycystic ovary syndrome (PCOS), whose aetiology is unknown, is predominately a familial syndrome but confirmation of candidate genes has proved elusive. The developmental hypothesis for the origin of PCOS suggests that exposure of the fetus to excess androgens influences imprinting, leading to altered genetic expression in adult life. The aim of this pilot study was to examine whet...

Background Saliva and tears are easy accessible fluids for biomarker analyses but a major drawback is that substantial proportion of patients with primary Sjogren’s syndrome (pSS) suffers from severe dryness, limited or no saliva tear to donate. Thus, novel non-invasive strategies applying state-of-the-art technologies should be welcomed. Objectives To evaluate if metabolome analysis sebum can ...