Primary cultured cardiomyocytes show spontaneous Ca2+ oscillations (SCOs) which not only govern contractile events, but undergo derangements that promote arrhythmogenesis through Ca2+ -dependent mechanism. We systematically examined influence on SCOs of an array of ion channel modifiers by recording intracellular Ca2+ dynamics in rat ventricular cardiomyocytes using Ca2+ specific fluorescence d...

the shanghai cooperation organization (sco) is developing into a major regional institution in the heart of central eurasia. to make any predictions about the sco, one must examine factors contributing to russian and chinese foreign policy behaviors in central asia. does the seductive presumption of a looming battle for control of eurasia smell of a new “great game” and great power rivalry? ans...

We present intermediate resolution spectroscopy and near infrared photometry of NOVA Sco 2001 (V1178 Sco), which was first detected May 13th 2001 and reported June 21th 2001, and obtained by us the same day. We also retrieved very accurate astrometry of the target in this very crowded field. This is needed to be able to do follow up observations of the postnova during the next years. The spectr...

regional organizations are established to achieve to strategic interests of the member countries based on common interests and goals. shanghai cooperation organization (sco) is considered as a regional organization. sco was formed in 2001 with the participation of china, russia, kazakhstan, kyrgyzstan, tajikistan and uzbekistan. this study attempts to analyze the reasons of india for trying to ...

The Bluetooth specification allows both asynchronous (ACL) and synchronous (SCO) links to be present in a piconet. However, the performance ofACL traffic rapidly deteriorates when an SCO link is present. This paper investigates the possibility of replacing the Bluetooth SCO connection with a QoS-constrained asynchronous link that uses multi-slot ACL packets. We have analyzed the performance of ...

The subcommissural organ (SCO) is a brain gland located in the roof of the third ventricle that releases glycoproteins into the cerebrospinal fluid, where they form a structure known as Reissner's fiber (RF). On the basis of SCO-spondin sequence (the major RF glycoprotein) and experimental findings, the SCO has been implicated in central nervous system development; however, its function(s) afte...

Neurofilaments (NFs) including neurofilament‑200 kDa (NF‑H), neurofilament‑165 kDa (NF‑M) and neurofilament‑68 kDa (NF‑L) are major protein constituents of the brain, and serve important roles in the regulation of axonal transport. NF alteration is a key feature in the pathogenesis of neurological disorders involving cognitive dysfunction. In the present study, cognitive impairments were invest...

The neural control of the subcommissural organ (SCO) has been partially characterized. The best known input is an important serotonergic innervation in the SCO of several mammals. In the rat, this innervation comes from raphe nuclei and appears to exert an inhibitory effect on the SCO activity. A GABAergic innervation has also been shown in the SCO of the rat and frog Rana perezi. In the rat, G...

The advancement of molecular electronics and spintronics requires novel hybrid materials with synergistic magnetic and electrical properties. The non-covalent functionalization of highly conductive graphene with magnetically bistable spin crossover (SCO) complexes may yield such a multifunctional material. In this regard, a graphene-Fe(ii) SCO complex hybrid (Gr-SCO) has been prepared by non-co...