نتایج جستجو برای: scd26

تعداد نتایج: 40  

2009
Loretta De Chiara Ana M. Rodríguez-Piñeiro Oscar J. Cordero Francisco J. Rodríguez-Berrocal Daniel Ayude Francisco J. Rivas-Hervada María Páez de la Cadena

INTRODUCTION Previous studies have suggested the use of soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. The aim of this study was to assess the sCD26 concentration in a large cohort to evaluate its association to epidemiologic parameters and CRC-related symptoms/pathologies. SUBJECTS AND METHODS Serum samples were collected from 2,75...

2015
Radwan H. Ahmed Hasniza Zaman Huri Zaid Al-Hamodi Sameer D. Salem Sekaran Muniandy Paul Proost

BACKGROUND A soluble form of CD26/dipeptidyl peptidase-IV (sCD26/DPP-IV) induces DPP-IV enzymatic activity that degrades incretin. We investigated fasting serum levels of sCD26/DPP-IV and active glucagon-like peptide-1 (GLP-1) in Malaysian patients with type 2 diabetes mellitus (T2DM) with and without metabolic syndrome (MetS), as well as the associations between sCD26/DPP-IV levels, MetS, and ...

2014
Loretta De Chiara Ana M. Rodríguez-Piñeiro Oscar J. Cordero Lidia Vázquez-Tuñas Daniel Ayude Francisco J. Rodríguez-Berrocal María Páez de la Cadena

One of the main aims of the follow-up after curative resection of colorectal cancer is the early detection and treatment of tumor recurrence. We previously demonstrated decreased preoperative soluble CD26 (sCD26) levels in serum from colorectal cancer patients. We extended now the study to investigate if sCD26 levels in postoperative serum serve as marker of recurrence of the disease during sur...

2016
Alireza Rafiei Abolghasem Ajami Araz Mohammad Mirabi Mohammad Jafar Saffar Omolbanin Amjadi Mohammad Reza Haghshenas Farshideh Abedian Pouya Khaje-Enayati

BACKGROUND Even without treatment, most acute hepatitis E virus (HEV) infected patients resolve HEV but sometimes the disease leads to acute liver failure, chronic infection, or extrahepatic symptoms. The mechanisms of HEV pathogenesis appear to be substantially immune mediated. However, the immune responses to HEV are not precisely identified. OBJECTIVES This study aimed to evaluate the Th1/...

2014
Nobukazu Fujimoto Kei Ohnuma Keisuke Aoe Osamu Hosono Taketo Yamada Takumi Kishimoto Chikao Morimoto

There is no established single diagnostic marker for malignant pleural mesothelioma (MPM). CD26 is a 110 kDa, multifunctional, membrane-bound glycoprotein that has dipeptidyl peptidase IV (DPPIV) enzyme activity. The aim of this study was to evaluate the clinical significance of soluble CD26 (sCD26) in patients with MPM. The study included 80 MPM patients, 79 subjects with past asbestos exposur...

Journal: :International immunology 1999
S Iwata N Yamaguchi Y Munakata H Ikushima J F Lee O Hosono S F Schlossman C Morimoto

CD26, a 110 kDa cell surface glycoprotein, exhibits dipeptidyl peptidase IV (DPPIV; EC 3.4.14.5) enzyme activity and plays an important role in T cell co-stimulation. In the present study, the function of CD26/DPPIV in transendothelial migration was examined using beta-chemokines as chemoattractants. When soluble recombinant CD26 (sCD26/DPPIV+) was added to the transendothelial chemotaxis syste...

2013
Jonas Söderholm Jesper Waldenström Galia Askarieh Massimo Pilli Pierre-Yves Bochud Francesco Negro Jean-Michel Pawlotsky Stefan Zeuzem Carlo Ferrari Gunnar Norkrans Rune Wejstål Johan Westin Avidan U. Neumann Bart L. Haagmans Magnus Lindh Gabriele Missale Kristoffer Hellstrand Martin Lagging

BACKGROUND Interferon and ribavirin therapy for chronic hepatitis C virus (HCV) infection yields sustained virological response (SVR) rates of 50-80%. Several factors such as non-1 genotype, beneficial IL28B genetic variants, low baseline IP-10, and the functionality of HCV-specific T cells predict SVR. With the pending introduction of new therapies for HCV entailing very rapid clearance of pla...

2013
Tetsurou Ikeda Emi Kumagai Satoshi Iwata Akio Yamakawa

CD26 is a 110-kDa multifunctional molecule having dipeptidyl peptidase IV (DPPIV) enzyme activity and is present on the surface of human T cells. Soluble CD26 (sCD26) exists in human blood and enhances the proliferation of peripheral T lymphocytes induced by tetanus toxoid (TT). The mechanisms by which CD26 enhances the activation of T cells and monocytes remain to be fully elucidated. In this ...

2006
Osamu Matsuno Eishi Miyazaki Shinichi Nureki Takuya Ueno Masaru Ando Toshihide Kumamoto

BACKGROUNDS CD26, a multifunctional T cell surface glycoprotein, is a type II transmembrane protein containing only six amino acid residues in its cytoplasmic region. In addition to its membrane form, CD26 exists in plasma in a soluble form (sCD26), which is thought to be the extracellular domain of the molecule cleaved from the cell surface. Recent studies indicated CD26 have an important role...

Journal: :Journal of investigational allergology & clinical immunology 2013
M Mahmoudi M Hedayat A Aghamohammadi N Rezaei

BACKGROUND Common variable immunodeficiency (CVID) is a heterogeneous group of disorders characterized by decreased serum immunoglobulin levels and increased susceptibility to recurrent bacterial infections. There is increasing evidence that the type 1 helper T cell (T(H)1)/T(H)2 cell balance is shifted towards a T(H) 1-type immune response in patients with CVID. This study was performed to mea...

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