a major hurdle in pharmaceutical formulation is water insolubility of most of drugs affecting their stability and bioavailability. if the drug is also insoluble in organic medium, it is difficult to deliver it in a sufficiently bioavailable form and hence it is a great challenge to formulation researchers to overcome such difficulty. although some approaches are available for enhancing the diss...

aim: to enhance the aqueous solubility of olanzapine by using the solid dispersion technique. solid dispersions of olanzapine were prepared by the dispersion method using using pgs and ssg as carriers. drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

The effect of ethanol addition to aqueous semi saturated NaCl solutions on the super saturation was studied. The amount of precipitated salt was found to increase as the percent of added ethanol increased. The rates of formation of precipitate were calculated and found to increase with decrease of the weighted average of the solvents mixture dielectric constant, , but levels out at  ≈ 50. The...

At present about 40% of the drugs being in the development pipelines are poorly soluble, even up to 60% of compounds coming directly from synthesis are poorly soluble [1]. Poor solubility is in most cases associated with poor bioavailability. According to the Noyes-Whitney law the dissolution velocity dc/dt depends on the saturation solubility cs. There are two basic approaches to overcome the ...

Solubilities of corundum (Al2O3) and wollastonite (CaSiO3) were measured in H2O–NaCl solutions at 800 C and 10 kbar and NaCl concentrations up to halite saturation by weight-loss methods. Additional data on quartz solubility at a single NaCl concentration were obtained as a supplement to previous work. Single crystals of synthetic corundum, natural wollastonite or natural quartz were equilibrat...

Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

The solid state properties and dissolution behavior of lamotrigine in its inclusion complex with βCyclodextrin were investigated.Preformulation study of lamotrigine was carried out. Dialysis study of lamotrigine with β-Cyclodextrin in pretreated dialysis bags showed that lamotrigine binds with βCyclodextrin in the ratio of 1:2. Solid dispersions were prepared by kneading and spray dried method....

The objective of the present investigation was to enhance the oral bioavailability of practically insoluble Candesartan cilexetil [CC] by preparing nanosuspension. The nanosuspension was prepared by media milling using zirconium oxide beads and converted to solid state by spray drying. The spray dried nanosuspension of CC [SDCN] was evaluated for particle size, zeta potential, saturation solubi...

AIM To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug-carrier ratios such as 1 : 1, 1 : 2, 1 : 4, 1 : 6, 1: 8 and 1 : 10 were tried for optimization. Characterization was done by phase solubility, in-vitro release, saturation solubility, permeat...