Four new species of Sapindaceae from the Guianas, South America, are described, illustrated and contrasted with their putative, relatives: Matayba ayangannensis Acev.-Rodr. a small shrub from Mt. Ayanganna, Guyana; and Paullinia degranvillei Acev.-Rodr., Paullinia oldemanii Acev.-Rodr., and Paullinia prevostiana Acev.-Rodr., three species of lianas from French Guiana.