Socio-economic predictors of chronic diseases in Ghana are not well understood and their influence has been relatively overlooked. This paper seeks to examine the influence of socio-economic predictors of chronic diseases in Ghanaians three different age groups. The data employed in the study were drawn from Global Ageing and Adult Health survey conducted in Ghana by SAGE and was based on the d...

Aim. To determine the characteristics of megajournal authors, the nature of the manuscripts they are submitting to these journals, factors influencing their decision to publish in a megajournal, sources of funding for article processing charges (APCs) or other fees and their likelihood of submitting to a megajournal in the future. Methods. Web-based survey of 2,128 authors who recently publishe...

Serial analysis of gene expression (SAGE) is a method for identifying and quantifying transcripts from eukaryotic genomes. Since its invention, SAGE has been widely applied to analyzing gene expression in many biological and medical studies. Vast amounts of SAGE data have been collected and more than a thousand SAGE-related studies have been published since the mid-1990s. The principle of SAGE ...

y In this paper, a space-alternating generalized expectation-maximization (SAGE) algorithm is presented for the numerical computation of maximum-likelihood (ML) and penalized maximum-likelihood (PML) estimates of the parameters of covariance matrices with linear structure for complex Gaussian processes. By using a less informative hidden-data space and a sequential parameter-update scheme, a SA...

Serial Analysis of Gene Expression, or SAGE, is a technology of measuring the expression levels of the mRNA transcripts. The result of a SAGE experiment is reported as a SAGE library, which contains the counts of various short segments (tags) of the cDNA clones. Through a close examination of the SAGE experiment protocol, we derive a new statistical model for the SAGE data, and give new tests f...

A comparison study of short SAGE versus GeneChip and long SAGE was conducted to determine if data were interchangeable between the techniques. Although SAGE and Affymetrix chip expression levels showed a significant correlation using the set of genes for which there was reliable and unambiguous mapping from tag-to-gene identification, correlation coefficients were low (0.51 for the Spearman's c...

A gene's expression pattern provides clues to its role in normal physiology and disease. To provide quantitative expression levels on a genome-wide scale, the Cancer Genome Anatomy Project (CGAP) uses serial analysis of gene expression (SAGE). Over 5 million transcript tags from more than 100 human cell types have been assembled. To enhance the utility of this data, the CGAP SAGE project create...

FoxA transcription factors play major roles in organ-specific gene expression, regulating, for example, glucagon expression in the pancreas, GLUT2 expression in the liver, and tyrosine hydroxylase expression in dopaminergic neurons. Organ-specific gene regulation by FoxA proteins is achieved through cooperative regulation with a broad array of transcription factors with more limited expression ...

Serial Analysis of Gene Expression (SAGE) is becoming a widely used gene expression profiling method for the study of development, cancer and other human diseases. Investigators using SAGE rely heavily on the quantitative aspect of this method for cataloging gene expression and comparing multiple SAGE libraries. We have developed additional computational and statistical tools to assess the qual...

The Mouse SAGE Site is a web-based database of all available public libraries generated by the Serial Analysis of Gene Expression (SAGE) from various mouse tissues and cell lines. The database contains mouse SAGE libraries organized in a uniform way and provides web-based tools for browsing, comparing and searching SAGE data with reliable tag-to-gene identification. A modified approach based on...