exploration of natural products with antitumoral effects such as etoposide, tenioposide, camptothecin and paclitaxel from conifers provoked us to do some research on anti-tumoral activity of iranian medicinal plants. ten different species of iranian conifers aerial parts were collected across the country. the relative potency of methanolic extract were investigated on the inhibition of topoisom...

NMR solution structure of the reduced form of thioredoxin 1 from Sacharomyces cerevisiae Anderson Sá Pinheiro, Gisele Cardoso Amorim, Luis Eduardo Soares Netto, Fábio C.L. Almeida, and Ana Paula Valente* 1 Centro Nacional de Ressonância Magnética Nucelar Jiri Jonas, Instituo de Bioquı́mica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro-RJ, Brasil 2 Instituto de Biologia, Universi...

Nowadays, DNA microarray technology provides biologists with the ability to measure the expression levels of thousands of genes in a single experiment. As data from such experiments accumulates, it appears possible to attempt a reverse engineering of the underlying regulatory interactions from the expression data itself. This may be achieved by using sophisticate data mining techniques that hav...

Previous works have already checked the relationship of a number of functional similarity scores with different types of biological information: sequences, protein families, expression profiles, pathways, literature, etc. This work aims to provide a review and a critical comparison of previously proposed similarity scores, to help in the decision of choosing the appropriate one for the problem ...

Most of the current codon usage bias computational approaches are only suitable for the comparison of codon usage bias within a single genome. Here we introduce a new informatics method, referred to as synonymous codon usage order (SCUO), to measure synonymous codon usage bias. In this method, we used Shannon informational theory to describe the SCUO of each gene using a value ranging from 0 to...

Fungal β-1,3-glucan glucanosyltransferases are glucan-remodeling enzymes that play important roles in cell wall integrity, and are essential for the viability of pathogenic fungi and yeasts. As such, they are considered possible drug targets, although inhibitors of this class of enzymes have not yet been reported. Herein we report a multidisciplinary approach based on a structure-guided design ...