نتایج جستجو برای: s retinoic acid

تعداد نتایج: 1400096  

امانی, مجتبی, عباسی, اسدالله, فکور, سینا, ماذنی, محمد, نجف زاده, نوروز, یلمه‌ها, یاسین,

Backgrounds and Objectives: All-trans retinoic acid (ATRA) which is a derivative of vitamin A, exert fundamental effects on regulation of cell growth, differenation and apoptosis. Recently, resistance to cisplatin and 5-fluorouracil developed in gastric adenocarcinoma and squamous cell carcinoma. In this study, we investigated the combination treatment of ATRA with cisplatin and 5-fluorouracil ...

2006
Peter C. Adamson Robert F. Murphy Karen A. Godwin Edgar H. Ulm Frank M. Balis

9-c/s-Retinoic acid is a naturally occurring biologically active retinola capable of binding and transactivating both the retinoic acid receptors and the retinoid X receptors. A study was performed to characterize the pharmacokinetics 9-c/s-retinoic acid following i.v. bolus administration in the nonhuman primate. Groups of three animals received i.v. bolus doses of 9-c/s-retinoic acid of eithe...

Journal: :The FEBS journal 2009
Jan P Schuchardt David Wahlström Joëlle Rüegg Norbert Giese Madalina Stefan Henning Hopf Ingemar Pongratz Helen Håkansson Gregor Eichele Katarina Pettersson Heinz Nau

Retinoic acid receptor (RAR) and retinoid X receptor are ligand-induced transcription factors that belong to the nuclear receptor family. The receptors are activated by small hydrophobic compounds, such as all-trans-retinoic acid and 9-cis-retinoic acid, respectively. Interestingly, these receptors are also targets for a number of exogenous compounds. In this study, we characterized the biologi...

تاتا, نسرین, حیدری تجدید, شیرین , نجف‌زاده, نوروز,

Background and Objective: Hair follicle stem cells are multipotent, located in the bulge area, and are highly proliferating. Retinoids have an effect on epidermal differentiation and keratinization. Retinoic acid is used to treat some skin diseases such as Melasma, Acne and Ichthyosis. So, the study of all-trans retinoic acid effect on hair follicle stem cells and determination of the effective...

امانی, مجتبی , ماذنی, محمد, نجف زاده, نوروز, عباسی, اسداالله ,

Introduction & Objective: All-trans retinoic acid, a derivative of retinoids, is widely used to in-duce prolifferation, differentiation and apoptosis in normal, precancareous and cancerous cells. Cisplatin, an effective drug for cancer treatment, induces apoptosis via cross-linking to DNA. Previous studies on ovarian and melanoma cancer cells have showed synergistic ef-fects of cisplatin and ...

خاکساری, دکتر محمد , رضازاده , دکتر مجتبی , شریعتی , مهدی ,

ABSTRACT: Retinoic acid "one of the derivatives of vitamin A "has different morphogenic and teratogenic effects on developing organs. For this reason, the present study is an attempt to examine the effects of retinoic acid on limb bud ,eye and body axis of chick embryo in the stages of 11-12 Humburger and Hamilton. The experiments cartied out in this study was based on 140 white eggs which h...

Journal: :physiology and pharmacology 0
siamak beheshti division of animal sciences, department of biology, faculty of sciences, university of isfahan, isfahan, iran azam soleimanipour division of animal sciences, department of biology, faculty of sciences, university of isfahan, isfahan, iran

introduction: retinoid signaling has been argued to have favorable effects on alzheimer's disease (ad). we studied the role of chronic intracerebroventricular (icv) injection of all-trans retinoic acid (atra) on the amyloid-beta (aβ) model of ad. methods: adult male rats weighing 260-330 g were divided into 12 groups of 8 each. six groups of rats received atra (3nm, 30nm, 3μm, 0.3mm, 30mm/...

Journal: :iranian biomedical journal 0
سید حسن افتخار واقفی seyed hassan eftekhar-vaghefi لیلا زحمتکش leila zahmatkesh پروین صالحی نژاد parvin salehinejad شهین توتونچی shahin totonchi علی شمس آرا ali shams-ara

background: retinoic acid as one of the most important regulators for cell differentiation was examined in this study for differentiation of human umbilical mesenchymal cells (hucm). methods: after isolation, hucm were evaluated for mesenchymal stem cell properties by flow cytometry and alkaline phosphatase assay. also, doubling time of the cells and their differentiation potential into adipoge...

Journal: :iranian journal of science and technology (sciences) 2005
a. amini

retinoic acid (ra) plays a key role in pattern formation along the major body axis and limbformation during vertebrate development. exposure to excessive retinoic acid (in uterus) generatescongenital malformations in limbs, craniofacial, cns, urogenital, heart, and axial skeletons. in thesestudies, seven groups of nmri pregnant mice were administered a single gavage dose of 100 mg /kgbody weigh...

Journal: :physiology and pharmacology 0
mahmoud aminizadeh mehdi abbasnejad dept. biology, shaheed bahonar university, kerman, iran ahmad ali moazedi ahmadali papahn

introduction: previous studies have shown that vitamin a and its derivatives such as retinoid and all-trans retinoic acid have a crucial role in memory, learning and synaptic plasticity. the receptors of vitamin a are seen in different parts of the brain such as hippocampus, where vitamin a has an important role in learning. in this study, the effect of intrahippocampal (ca1) injection of all –...

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