Background: The increasing use of nuclear radiation for human welfare necessitates the search for new, safe, cost effective radio protectors not only for the personnel’s charged with the responsibility of working or testing with radiations in laboratories, but also for general public. With this view the present study has been undertaken to determine the deleterious effects of sub lethal g...

The gamma-subunit of retinal rod-outer-segment phosphodiesterase (PDE-gamma) is a multifunctional protein which interacts directly with both of the catalytic subunits of PDE (PDE alpha/beta) and the alpha-subunit of the retinal G (guanine-nucleotide-binding)-protein transducin alpha (T alpha). We have previously reported that the PDE gamma binds to T alpha at residue nos. 24-45 [Morrison. Rider...

The binding of cGMP to the noncatalytic sites on two isoforms of the phosphodiesterase (PDE) from mammalian rod outer segments has been characterized to evaluate their role in regulating PDE during phototransduction. Nonactivated, membrane-associated PDE (PDE-M, alpha beta gamma2) has one exchangeable site for cGMP binding; endogenous cGMP remains nonexchangeable at the second site. Non-activat...

The promyelocytic HL60 cell can be differentiated with dimethyl sulphoxide or dibutyryl cyclic AMP leading to the appearance of fMetLeuPhe receptors on the cell surface. G-protein-stimulated polyphosphoinositide phosphodiesterase (PPI-pde) activity was assessed in membranes prepared from both differentiated and non-differentiated HL60 cells. Both the extent of the response and the rank order of...

Contents 1. Introduction. 2. Models of PDE 's in the 18th and 19th century. 3. Methods of calculating solutions in the 19th century. 4. Developments of rigorous theories of solvability in the last decades of the 19th century. 5. The period 18901900: the beginning of modern PDE and the work of Poincare. 6. The Hilbert programs. 7. S. Bernstein and the beginning of a priori estimates. 8. Solvabil...

This letter presents some special features of a class of integrable PDE’s admitting billiard-type solutions, which set them apart from equations whose solutions are smooth, such as the KdV equation. These billiard solutions are weak solutions that are piecewise smooth and have first derivative discontinuities at peaks in their profiles. A connection is established between the peak locations and...

The spine of an object is an entity that can characterise the object’s topology and describes the object by a lower dimension. It has an intuitive appeal for supporting geometric modelling operations. The aim of this paper is to show how a spine for a PDE surface can be generated. For the purpose of the work presented here an analytic solution form for the chosen PDE is utilised. It is shown th...