نتایج جستجو برای: s flexneri

تعداد نتایج: 712359  

2014
Sofie Livio Nancy A. Strockbine Sandra Panchalingam Sharon M. Tennant Eileen M. Barry Mark E. Marohn Martin Antonio Anowar Hossain Inacio Mandomando John B. Ochieng Joseph O. Oundo Shahida Qureshi Thandavarayan Ramamurthy Boubou Tamboura Richard A. Adegbola Mohammed Jahangir Hossain Debasish Saha Sunil Sen Abu Syed Golam Faruque Pedro L. Alonso Robert F. Breiman Anita K. M. Zaidi Dipika Sur Samba O. Sow Lynette Y. Berkeley Ciara E. O'Reilly Eric D. Mintz Kousick Biswas Dani Cohen Tamer H. Farag Dilruba Nasrin Yukun Wu William C. Blackwelder Karen L. Kotloff James P. Nataro Myron M. Levine

BACKGROUND Shigella, a major diarrheal disease pathogen worldwide, is the target of vaccine development. The Global Enteric Multicenter Study (GEMS) investigated burden and etiology of moderate-to-severe diarrheal disease in children aged <60 months and matched controls without diarrhea during 3 years at 4 sites in Africa and 3 in Asia. Shigella was 1 of the 4 most common pathogens across sites...

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Journal: Iranian Biomedical Journal 2007
Farideh Ghazi, Jamileh Nowroozi, Mojdeh Hakemi Vala, Parvaneh Nabavi Tabatabai, Saeed Haghighi,

The aim of this study was to compare invasive and non-invasive strains of Shigella flexneri isolated from Tehran by a 120 kDa protein band by SDS-PAGE, electron microscopy of cell culture and Congo red dye methods. Methods: S. flexneri strains were isolated by standard bacterial methods from fecal specimens of children attending to the 3 children’s hospitals. Phenotype analysis for screening v...

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2014
Divya T. George Carolyn A. Behm David H. Hall Ulrike Mathesius Melanie Rug Ken C. Q. Nguyen Naresh K. Verma

The Gram-negative bacterium Shigella flexneri is the causative agent of shigellosis, a diarrhoeal disease also known as bacillary dysentery. S. flexneri infects the colonic and rectal epithelia of its primate host and induces a cascade of inflammatory responses that culminates in the destruction of the host intestinal lining. Molecular characterization of host-pathogen interactions in this infe...

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Journal: :PLoS ONE 2009
Emmanuel Coron Mathurin Flamant Philippe Aubert Thilo Wedel Thierry Pedron Eric Letessier Jean P. Galmiche Philippe J. Sansonetti Michel Neunlist

BACKGROUND Shigella, an enteroinvasive bacteria induces a major inflammatory response responsible for acute rectocolitis in humans. However, early effect of Shigella flexneri (S. flexneri) infection upon the human mucosa and its microenvironement, in particular the enteric nervous system, remains currently unknown. Therefore, in this study, we sought to characterize ex vivo the early events of ...

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Journal: :Infection and immunity 1987
L S Baron D J Kopecko S B Formal R Seid P Guerry C Powell

For protection against dysentery caused by Shigella flexneri 2a, an in vivo-constructed recombinant plasmid with genes specifying the S. flexneri type and group antigens located near the pro (min 6) and his (min 44) chromosomal markers, respectively, was made and transferred to the galE Salmonella typhi strain Ty21a. Strain Ty21a carrying this recombinant plasmid was shown by immunological and ...

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Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Ellen T Arena Francois-Xavier Campbell-Valois Jean-Yves Tinevez Giulia Nigro Martin Sachse Maryse Moya-Nilges Katharina Nothelfer Benoit Marteyn Spencer L Shorte Philippe J Sansonetti

Few studies within the pathogenic field have used advanced imaging and analytical tools to quantitatively measure pathogenicity in vivo. In this work, we present a novel approach for the investigation of host-pathogen processes based on medium-throughput 3D fluorescence imaging. The guinea pig model for Shigella flexneri invasion of the colonic mucosa was used to monitor the infectious process ...

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2006
Je Chul Lee Young Sook Jeong Jae Young Oh Hee Young Kang Kwang Hoon Kim Jungmin Kim Yoo Chul Lee Dong Taek Cho Sung Yong Seol

Shigellosis is an acute diarrheal disease caused by bacteria of the genus Shigella. Following the occurrence of a large outbreak of shigellosis as well as sporadic cases since 1998, shigellosis has been a major health problem in Korea. There have been major changes in epidemiology during the last five decades concerning shigellosis in terms of total incidence of shigellosis, prevalence of certa...

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Journal: :Infection and immunity 1999
F R Noriega F M Liao D R Maneval S Ren S B Formal M M Levine

Based upon the lipopolysaccharide (LPS) structure and antigenicity of Shigella group B, a strategy for broad cross-protection against 14 Shigella flexneri serotypes was designed. This strategy involves the use of two S. flexneri serotypes (2a and 3a), which together bear the all of the major antigenic group factors of this group. The novel attenuated strains used in these studies were S. flexne...

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2012
Sahyun Hong Injun Cha Nan-Ok Kim Seong-Han Kim Kyung-Tae Jung Je-Hee Lee Dong-Wook Kim Mi-Sun Park Yeon-Ho Kang

OBJECTIVES We aimed at evaluating the virulence of atypical Shigella flexneri II:(3)4,7(8) by DNA microarray and invasion assay. METHODS We used a customized S. flexneri DNA microarray to analyze an atypical S. flexneri II:(3)4,7(8) gene expression profile and compared it with that of the S. flexneri 2b strain. RESULTS Approximately one-quarter of the atypical S. flexneri II:(3)4,7(8) strai...

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Journal: :Infection and immunity 2002
Lucy J Hathaway George E Griffin Philippe J Sansonetti Jonathan D Edgeworth

Shigella flexneri infection of human macrophages is followed by rapid bacterial escape into the cytosol and secretion of IpaB, which activates caspase-1 to mediate cell death and release of mature interleukin (IL)-1 beta. Here we report a different outcome following infection of human peripheral blood monocytes. S. flexneri infects monocytes inefficiently in the absence of complement and, follo...

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