background: a lot of remedies, mostly plant based, were mentioned in the persian old pharmacopoeias for promoting of burn and wound healing and tissue repairing. the efficacy of most of these old remedies is unexplored till now. adiantum capillus‑veneris from adiantaceae family is one of them that was used to treating of some kinds of chronic wounds. methods: methanol extract was fractionated t...

The increasingly large number of chemicals introduced onto the market and into the environment has necessitated the monitoring of environmental materials and specimen banking, as well as the development of rapid and reliable methods for the evaluation of toxicity. The Hen's Egg Test, or Hühner-Embryonen-Test (HET) is a rapid, sensitive and inexpensive toxicity test and can give information on e...

Abstract: Aim: According to WHO, dental caries is the most prevalent oral disease, and its progression leads tooth loss. Clinical management of focuses on severity extent disease with main aim, i.e., ‘art’ creating a good restoration. Recently, it has been reported that aspirin can stimulate existing stem cells regenerate damaged teeth. But, therapeutic effectiveness drug depends developing sui...

Accurate methods that test the eye irritation potential of chemicals, which do not involve the use of animals, are needed to meet new regulatory standards. We evaluated the applicability and predictive capacity of five in vitro tests for eye irritation: the Hen's Egg Test-Chorioallantoic Membrane (HET-CAM) assay; the Chorioallantoic Membrane-Trypan Blue Staining (CAM-TBS) assay; the Fluorescein...

The present paper is an attempt to investigate the eye irritation potential of aqueous leaf extract of Achyranthes aspera by in vitro, Hen's Egg Chorioallantoic Membrane Test (HET-CAM) and in vivo acute eye irritation test in rabbits. The irritation score (IS) obtained after treatment of the extract on HET-CAM is 0.07 and that of in rabbits is 0.55, Which does not comes under either category 1 ...

Current in vivo models for testing biomaterials are time and labor intensive as well as expensive. This article describes a new approach for testing biomaterials in vivo using the chorioallantoic membrane (CAM) of the developing chicken embryo, as an alternative to the traditional mammalian models. Fertilized chicken eggs were incubated for 4 days, at which time a small window was cut in the sh...

Nanoemulsions (NE) are isotropic, dispersions of oil, water, surfactant(s) and cosurfactant(s). A range components (11 surfactants, nine cosurfactants, five oils) were investigated as potential excipients for preparation ketorolac tromethamine (KT) ocular nanoemulsion. Diol cosurfactants the effect their carbon chain length dielectric constant (DEC), Log P, HLB on saturation solubility KT. Hen’...