mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. it has shown a better efficacy than other drugs in this group. for assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. in this study mutagenic effect of mebudipine was evaluated using ames assay that could assess the mutageni...

Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...

Metabolic activation of benzene by rat liver microsomes and a reduced nicotinamide adenine dinucleotide phosphate-generating system (S-9 mix) induced sister chromatid exchanges (SCEs) and cell division delays in cultured human lymphocytes. There were optimal concentrations of S-9 mix for the conversion of benzene into the active metabolites that exerted these cytotoxic effects. Reduced glutathi...

Metabolic activation of benzene by rat liver microsomes and a reduced nicotinamide adenine dinucleotide phosphate-gen erating system (S-9 mix) induced sister chromatid exchanges (SCEs) and cell division delays in cultured human lymphocytes. There were optimal concentrations of S-9 mix for the conver sion of benzene into the active metabolites that exerted these cytotoxic effects. Reduced glutat...

Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...

N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN), which specifically induces bladder tumors, was shown to be mutagenic to Salmonella typhimurium strains TA 1535 and TA100 in the presence of an S-9 mix prepared from the liver of rats treated with polychlorinated biphenyl. Reduced nicotinamide adenine dinucleotide was a more effective cofactor than reduced nicotinamide adenine dinucleotide phosphate i...

Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...

Authors: Nadiia Artyukhova, ORCID: https://orcid.org/0000-0002-2408-5737 PhD, Associated Professor, Sumy State University, Ukraine Jan Krmela, https://orcid.org/0000-0001-9767-9870 University of Pardubice, Czech Republic Vladimira Krmelova, https://orcid.org/0000-0002-3822-3416 Alexander Dubcek Trencin, Slovak Dastan Ospanov, https://orcid.org/0000-0003-0401-180X Saken Seifullin Kazakh Agrotech...