Background: DNA damage is one of the major consequences of radiation exposure onto the biological systems. A series of compounds including flavanoids were found to render DNA protection against radiation damage. In this study we elucidated the potential of rutin and rutin hydrate to protect plasmid DNA against damage induced by irradiation. Materials and Methods: DPPH and hydroxyl radical scave...

background: dna damage is one of the major consequences of radiation exposure onto the biological systems. a series of compounds including flavanoids were found to render dna protection against radiation damage. in this study we elucidated the potential of rutin and rutin hydrate to protect plasmid dna against damage induced by irradiation. materials and methods: dpph and hydroxyl radical scave...

This study examined the effect of methanolic extract of Morinda citrifolia Linn. (MMC) and its bioactive principles, scopoletin and rutin, on dopamine- and noradrenaline-evoked contractility in isolated rat vas deferens preparations. MMC (1-40 mg/mL), scopoletin (1-200 μg/mL), and rutin hydrate (0.6-312.6 μg/mL) dose-dependently inhibited the contractility evoked by submaximal concentrations of...

PURPOSE Gardenia jasminoides is a traditional medicinal plant rich in anti-inflammatory flavonoids and phenolic compounds and used for the treatment of inflammatory diseases and pain. In this present study, antioxidant potential of Gardenia jasminoides leaves extract was evaluated by using various antioxidant assays. METHODS Various antioxidant assays such as 1, 1-diphenyl-2-picrylhydrazyl (D...

Background: DNA damage is one of the major consequences of radia on exposure onto the biological systems. A series of compounds including flavanoids were found to render DNA protec on against radia on damage. In this study we elucidated the poten al of ru n and ru n hydrate to protect plasmid DNA against damage induced by irradia on. Materials and Methods: DPPH and hydroxyl radical scavenging a...

This study investigated the antioxidant activity of one hundred kinds of pure chemical compounds found within a number of natural substances and oriental medicinal herbs (OMH). Three different methods were used to evaluate the antioxidant activity of DPPH radical-scavenging activity, ABTS radical-scavenging activity, and online screening HPLC-ABTS assays. The results indicated that 17 compounds...

BACKGROUND Exogenous pretreatment of oxidative stress on callus cultures of Bellis perennis L. (common daisy) induced catalase (CAT), superoxide dismutase (SOD), total phenolic, total flavonoid, total protein and selected commercial phenolic compounds production and accumulation. MATERIALS AND METHODS The callus culture obtained from B. perennis pedicel explants was incubated on Murashige and...

A high-performance liquid chromatographic method with gradient elution and diode-array detection was developed to quantify free phenolic acids (gallic, vanillic, chlorogenic, caffeic, syringic, p-coumaric, ferulic, sinapic, salycilic, elagic and trans-cinnamic), flavonoids (catechin, epicatechin, rutin, myricetin and quercetin) and juglone in walnut leaves. Chromatographic separation was perfor...

Neutrophil extracellular traps (NETs) have been suggested to play a pathophysiological role in several autoimmune diseases. Since NET-formation in response to several biological and chemical stimuli is mostly ROS dependent, in theory any substance that inhibits or scavenges ROS could prevent ROS-dependent NET release. Therefore, in the present comprehensive study, several antioxidative substanc...

A highly soluble quercetin glycoside, alphaG-rutin, is a glucose adduct of insoluble rutin, and intestinal absorption and metabolism of alphaG-rutin has not been known. We investigated the intestinal absorption and metabolism of alphaG-rutin by using portal and duodenal cannulated rats and the isolated rat intestinal mucosa. After a duodenal instillation of alphaG-rutin (150 mumol), intact alph...