Inhibition of the delayed-rectifier potassium channel current, human ether-a-go-go (hERG), by pharmaceutical agents can lead to acquired long QT syndrome and the generation of potentially lethal arrhythmias and sudden death. There remains an unmet need for higher-throughput assays to screen compounds in preclinical development for the potential to block hERG and cause QT prolongation. We evalua...

Isotopic effects occuring during the evaporation of microgram quantities of chemically pure rubidium, potassium and lithium compounds are studied. The measured isotopic ratios show a time dependent variation corresponding to a RAYLEIGH distillation. The fractionation factor is equal to the square root of the ratio of the masses. The highest observed enrichments are 45% for lithium, 10% for pota...

Electrochemical intercalation behaviors of alkali metals into graphite have been vigorously studied in academic and industrial fields, whereas their mechanisms are still unclarified. In this study, we report a novel rubidium-ion battery utilizing an ionic liquid electrolyte natural as the negative electrode material operating at room temperature. The electrochemical phase evolution behavior rub...

(8 7Rb/8 5Rb) from chloride ( 8 7 Rb/ 8 5 Rb) from nitrate 1.011 ± 0 . 0 0 7 1.014 ± 0.008 Table 2. Difference in the measured isotopic abundance of rubidium due to various chemical compounds. Given are the ratios of 87Rb/85Rb ratios obtained from the two different chemical compounds indicated in the first column. Absolute ratios and standard deviations were calculated in a corresponding manner...

The introduction of parallel patch clamp instruments offers the promise of moderate-throughput, high-fidelity voltage clamp for drug screening assays. One such device, the IonWorks HT (Molecular Devices, Sunnyvale, CA), was evaluated and compared to conventional human ethera- go-go-related gene (hERG) patch clamp data and an alternative functional screen based on rubidium flux. Data generated b...

Rubidium concentrations in seawater from various locations and depths to 3,900 m have been determined using two independent techniques--direct flame photometry and mass spectrometry. Results of these two techniques agree within estimated errors and indicate that the rubidium content in the oceans is uniform within H$% with values varying about 120 pg/liter. Sediment from the sea floor below a d...

By DTA and visual methods the phase diagrams of the ten binary systems formed by lithium, sodium, potassium, rubidium and cesium bromide with barium or strontium bromide have been drawn. Moreover, the fusion thermal effects regarding the eutectics and the congruent compounds singled out in the systems have been evaluated. The general thermodynamic behaviour of these systems is discussed in comp...

To study the short-term uptake of potassium across the basolateral membrane into individual tubule cells, rubidium was used and measured by electron microprobe analysis. Changes of rubidium uptake were interpreted to reflect altered sodium entry and basolateral Na-K-ATPase activity. The effects of hydrochlorothiazide, amiloride and furosemide were determined in saline-loaded animals. Hydrochlor...

BACKGROUND Depression may induce malnutrition, but, as a paradoxical hypothesis, malnutrition may induce depression. This relationship, of course, depends on how we define malnutrition. CURRENT KNOWLEDGE Rubidium is a trace element strongly linked with depression, and is deficient in uremia sufferers. However, in uremic patients, rubidium deficiency is more evident during predialysis, as it i...